中医湿病的现代认识

DOI10．13288/j．11－2166/r．2015．13．003ZYSNXD－CC－MZY02014ZＲ1413200*[e-mail]1361179541612333*1.2212000402.3.。“”“”。“”。“”。“”。11.1“”。。《·》“”、、、、“”。“”《·》“”《·》、、、、、《·》“”。1.2。《·》“”《·》“”、、、、、、。。。《·》“”。。。、、。、、“……”《·》“”《·》。、、、、、、、、、、、·9801·201575613JournalofTraditionalChineseMedicine2015Vol．56No．13、。2《》“”“”。。2.1《·》“。”。AVP、ALD1。2。NT、NT3。2.2。HpHp4。、、、、、5。。《·》“。”“”。6。———IＲIＲ。IＲαTNF-α、6IL-6、8IL-8CCＲP、1PAI-1IＲ。IＲ、、、IＲIKK/NF-KB、c-JunJNK、CPKC7－8。2.3“”“…………。”、、。。。49－121NO2、、、3P、-1ICAM-1-1VCAM-1、、4OSＲOSNOＲOSPＲＲsPＲＲs。·0901·201575613JournalofTraditionalChineseMedicine2015Vol．56No．1313－14。300。3、。、、、、、、、、、、、。。3《·》“……”。《·》“……………………”。。。Na+-K+-ATP15。TC、TG、VLDL-c、HDL-cNa+-K+-ATP16、。、、ATP/5。。、、。、、。4“”“”、、、、、、、17－18。“”、。“”。19－20、、、、、、、oatp2b1、、、。“”“”“”“”“”“”“”。“”。·1901·201575613JournalofTraditionalChineseMedicine2015Vol．56No．13/“”“”“”“”。“”“”。/、。1.J.200512126-27.2.J.19951152-54.3.J.200819112781-2782.4.J.19972410453-454.5.J.1999408496-498.6.J.20041935-6.7EsserNLegrand-PoelsSPietteJetal.Inflammationasalinkbetweenobesitymetabolicsyndromeandtype2diabetesJ.DiabetesＲesClinPract20141052141-150.8O'SullivanLALiongueCLewisＲSetal.CytokinereceptorsignalingthroughtheJak-Stat-SocspathwayindiseaseJ.MolImmunol200744102497-2506.9StokesKYGurwaraSGrangerDN.T-cellderivedinterferon-gammacontributestoarteriolardysfunctiondur-ingacutehyper-cholesterolemiaJ.ArteriosclerThrombVascBiol20072791998-2004.10NaghaviMFalkEHechtHSetal.FromvulnerableplaquetovulnerablepatientPartⅢexecutivesummaryoftheScreeningforHeartAttackPreventionandEduca-tionSHAPETaskForcereportJ.AmJCardiol2006982A2H-15H.11GillＲTsungABilliarT.LinkingoxidativestresstoinflammationToll-likereceptorsJ.FreeＲadicBiolMed20104891121-1132.12KulinskyVI.BiochemicalaspectsofinflammationJ．BiochemistryMoscow2007726595-607.13MoriNHorieYNimuraYetal.Hepaticmicrovascularresponsestoischemia-reperfusioninlow-densitylipopro-teinreceptorknockoutmiceJ.AmJPhysiolGastrointestLiverPhysiol20002796G1257-G1264．14StokesKYClantonECClementsKPetal.Ｒoleofinterferon-gammainhypercholesterolemia-inducedleukocyte-endothelialcelladhesionJ.Circulation2003107162140-2145.15.Na+-K+-ATPJ.200023430-33.16.、、Na+-K+-ATPJ.19951239-41.17.Th1/Th2J.200462181-183.18.J.2000208596-598.19.Oatp2a1J.20112971516-1519.20.AA-Ioatp2b1J.2014214349-352.TheModernUnderstandingofWetDiseaseinTraditionalChineseMedicineWANGHaidong1WUQing2WANGXiuwei3WANGShaomo3WANGQingqi31．HuadongHospitalFudanUniversityShanghai2000402．ShanghaiGeneralHospitalShanghaiJiaoTongUniversity3．LonghuaHospitalShanghaiUniversityofTraditionalChineseMedicineABSTＲACTThispaperbrieflysummarizedtheknowledgeandthefeaturesofwetdiseaseintraditionalChinesemedicine．Combinedwithmodernmedicalstudytowetdiseasetheauthorsputforwardthatpathologicalmechanismofwetdiseasewasthebeginningstageofmicrocirculationmetabolismdisordersinlocaltissueandinflammatoryreaction．Thedevelopmentofwetdiseasewasthemanifestationofthebody'senergymetabolicdisordersinlocallesiontissue．Dysfunctionof“spleenQiscattersessence”wasthe“key”andtherootcausefortheemergenceofwetdisease．KeywordswetdiseasemicrocirculationdisturbanceinflammatoryreactionenergymetabolismdisturbancespleenQiscattersessence2014－10－152014－12－11·2901·201575613JournalofTraditionalChineseMedicine2015Vol．56No．13