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20107化学试剂,2010,32(7),608~612李翠苹,曹树稳*,余燕影(,330031):,:;;:Q946.83:A:02583283(2010)07060805:20090608:(20962014):(1986),,,,(Dihydromyricetin,DMY)(),KotakeKubota1940(AMeliaefolia),1996[1],DMYDMY30%[2],(Ampelopsisgrossedentata),,,400~1300m,,Structureofdihydromyricetin111[3]DMY;,[4]:DMY(10gkg-1,05gkg-1)(10gkg-1),DMY,DMY,(10g/kg)[5]DMY,:DMY,[6]DMY,176g/L,Matsumoto[7],DMYladosporiumherbarum,DMY,DMY412Oshima[8]DMYHase[9]DMY,DMYLDHLDH,(SOD)DMYDDMY608327:DMY,M,,,DMY,[10]13Hase[9]DMY;DMY,,DMY,,,[11],,,,,DMY,DMY,DMY14[11]DMY(NE)K+,DMY[12],DMYNECa2+,NECa2+,DMY(PDC),[13]D,DMY,8w,2h:DMY,[4],TCTG,HDLC,DMY,,15,,Holton[14]DMY,pH(70)(30)3,5,DMY,,,[15]16:DMY[16],DPPHDMY3(Pouteria)[17],DMYIC50[18]DMYMDA,;[19](NBT)Cu2+H2O2,DMY,:DMYO-2OHROO900%839%639%,DMY[20]:,DMYTBHQ,Vc,,TBHQ;DMY12m[17]:DMY(001%~004%),TBHQDMYFeSO4Fe2+,Fe2+DMY,[21]:99%DMY,001%002%003%004%,DPPH733%814%877%915%17DMYKBMCF760920107,ED500620g/mL[22],DMYAGZY2832a,DMY204080mol/L,B16,361%596%791%;B16,516%565%668%;B16,DMY[23]:DMY100200250mg/kg,2105B1618d,B16,310%406%612%18DMY(HIV1),HIV1,P24DMYHIV1SF33MT4,P24EC5001750024mg/mL,MT4HIV1SF33,EC5002290197mg/mL,HIV1SF33,EC5001790348mg/mL[24]DMY[25],20,2050nmol/LED5033mol/L[26][27]DMY,;DMY[28]DMY,,(FCM),DMYH2O22DMY,pH9,,Fe3+Al3+Cu2+DMY,DMY[29],,3,,,,,,[30],,,,DMY:1);2);3)21:1),,;2),,,;3),,,;4),;5),,,,DMY,,[31]DMY80g/L,300g/L,5000L-1,pH50,4020h,DMY,53%,1589m,DMY22[32]:DMY6:3OH4OH5OH5OH3OH7OH;DMY,64OH5OH3OH7OH5OH3OH,DMY,,,Matsumoto[7]DMY,DMY4610327:[33]DMY,,BHT,005%DMY002%TBHQ[34]DMY,DMY[35]DMY,DMY,DMY,,[36],DMY,DMY23[37]DMYZn2+Ca2+Fe3+,,DMYOH,80%;,20%[38][39]DMYFe,,DMY,DMY,,,DMY3DMY,,,,,,DMY,,,DMY,,,();SchiffBase():[1],.[J].,1996,31(8):458461.[2]PANXuejun,NIUGuoguang,LIUHuizhou.ComparisonofmicrowaveassistedextractionandconventionalextractiontechniquesfortheextractionoftanshinonesfromSalviamiltiorrhizabunge[J].Biochem.Eng.J.,2002,1(12):7177.[3],,.[J].,1995,17(4):3940.[4],,,.[J].,1998,4(3):4244.[5],,.[J].,2003,28(1):44.[6],,.[J].,2008,35(2):239242.[7]MATSUMOTOT,AMPELOPSINTS.AmajorantifungalconstituentfromSalixsachalinensis,anditsmethylethers[J].Nipponnogeikagakukaishijournalofthejapansocietyforbiosciencebiotechnologyandagrochemistry,2001,75(6):659667.[8]OSHIMAY,AMPELOPSINSDFH,AMPELOPSINEC.Oligostilbenesfromampelopsisbrevipedunculatavarhanceiroots[J].phytochemistry(oxford),1993,33(1):179182.[9]HASEK,OHSUGIM,BASNETP,eta.lHepatoprotectiveeffectofhoveniadulcisthunb.OnexperimentalliverinjuriesinducedbycarbontetrachlorideorDgalactosamine/lipopolysaccharide[J].Biol.Pharm.Bull.,1997,20(4):381385.[10]YABEN,TANAKAK,MATSUIH,eta.lAnethanolextractofampelopsisbrevipedunculata(vitaceae)berriesdecreasesferrousirorrstimulatedhepatocyteinjuryinculture[J].J.Ethnopharmacol.,1998,59(3):147159.[11],.[J].,1999,30(6):459463.[12],,.[J].,1997,14(2):811.[13],,.[J].,2008,25(10):76861120107790.[14]HOLTONTA,TANAKAY.Bluerosesapigmentofourimagination[J].TrendsinBiotechnol.,1994,12(2):4042.[15]SUZUKIK,TSUDAS,FUKUIY.Molecularcharacterizationofroseflavonoidbiosynthesisgenesandtheirapplicationinpetunia[J].Biotechnol.&Biotechnol.equip.,2000,14(2):5662.[16]MURAKAMITT,MIYAKOSHIM,ARAHOD,eta.lHepatoprotectiveactivityoftocha,thestemsandleavesofampelopsisgrossedentataandampelopsin[J].Biofactors,2004,21(1/4):175178.[17],,,.()[J].,2003,38(4):241244.[18]MAJun,YANGHu,iBASILEMJ,eta.lAnalysisofpolyphenolicantioxidantsfromthefruitsofthreepouteriaspeciesbyselectedionmonitoringliquidchromatographymassspectrometry[J].J.Agri.FoodChem.,2004,52(19):58735878.[19],,.[J].,2007,28(9):4345.[20],.[J].,2008,1(27):4952.[21],,,.[J].,2003,28(12):11881190.[22],,.AGZY2832a[J].,2008,24(5):626630.[23],.[J].,2003,22(4):363367.[24]LIUDeyu,YEJiantao,YANGWenhu,ieta.lAmpelopsin,asmallmoleculeinhibitorofHIV1infectiontargetingHIVentry[J].Biomed.Environ.Sci.,2004,17(2):153164.[25]TOWATARIK,YOSHIDAK,MORIN,eta.lPolyphenolsfromtheheartwoodofcercidiphyllumjaponicumandtheireffectsonproliferationofmousehairepithelialcells[J].Planta.Med.,2002,68(11):995998.[26]KECKEISK,SARKERSD,DINANL.Resveratroltypeoligostilbenesfromirisclarkeiantagonize202hydroxyecdysoneactioninthedrosophilamelanogasterB()cellline[J].Cell.Mol.Life.Sci.,2000,57(2):333.[27],,.[J].,2008,19(9):20782081.[28],,.[J].,2008,1(42):46.[29],,,.[J].,2007,16(22):18881900.[30],,.[J].,2002,22(3):220226.[31],,.[J].,2005,24(6):9294.[32],,.[J].,2007,67(5):198201.[33],,.[J].,2006,18(2):260262.[34],,.[J].,2005,26(9):7376.[35],.:CN200410026610.5[P].20050928.[36],,.[C]//.:,2007.[37].[D].,2008:3341.[38],,.[J].,2009,31(1),3134.[39],,,.[J].,2006,53(1):166168.AdvanceinresearchondihydromyricetinLICuiping,CAOShuwen*,YUYanying(DepartmentofChemistry,NanchangUniversity,Nanchang330031,China),HuaxueShij,i2010,32(7),608~612Abstract:Dihydromyricetin,whichisthemaineffectivechemicalconstituentofAmpelopsisgrossedentata,hasawiderangeofbiologicalactivities,suchasantitumor,antioxidation,antibacterialproperties.Thestudyonbiologicalactivitiesandchemicalmodificationofdihydromyricetinwasreviewed.Keywords:dihydromyricetin;biologicalactivities;chemicalmodification612