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全球治疗性单克隆抗体上市情况列表序号商品名英文名中文名研发公司类型作用靶点适应症上市国家及时间1OKT3muromonab-CD3J&J鼠源抗体Tcellinhibitor抗移植排斥1986美国等2Iort3muromonab-CD3鼠源CD3单抗CenterofMolecularImmunology鼠源抗体CD3antagonistTellinhibitor抗移植排斥1995印度3RemovabcatumaxomabTrionPharma鼠源抗体CD3antagonistEGFRantagonist胰腺癌2009德国4ABcreamanti-IL-8MAbsYesBiotech鼠源抗体IL-8antagonist银屑病2004中国5Rituxanrituximab利妥昔单抗BiogenIdec人鼠嵌合抗体CD20抗肿瘤，类风湿1997美国等多国6Erbituxcetuximab西妥昔单抗EliLilly人鼠嵌合抗体EGFRantagonist抗肿瘤2003瑞士等国7ClotinabISUABXIS人鼠嵌合抗体GPllbIIIareceptorantagonist抗凝，心血管印度，巴西上市8ReoProabciximab阿昔单抗J&J人鼠嵌合抗体GPllbIIIareceptorantagonist抗凝，心血管1995美国等国9Remicadeinfliximab英夫利昔单抗J&J人鼠嵌合抗体TNF-αantagonist类风湿，克隆氏病等1998美国等国10simulectbasiliximab巴利昔单抗Novartis人鼠嵌合抗体IL-2receptorantagonist抗移植排斥1998美国等国11soliriseculizumabAlexion人源化抗体ComplementfactorC5inhibitor溶血性贫血2007美国等国12Synagispalivizumab帕利珠单抗AstraZeneca人源化抗体免疫调节呼吸道合胞病毒1998美国等国13Zenapaxdaclizumab抗Tac单抗FacetBiotech人源化抗体IL-2receptorantagonist抗移植排斥1997美国等序号商品名英文名中文名研发公司类型作用靶点适应症上市国家及时间14Campathalemtuzumab阿伦珠单抗BTG人源化抗体LymphocyteinhibitorCD52inhibitor白血病，移植排斥等2001美国等国15BioMabnimotuzumabCenterofMolecularImmunology人源化抗体EGFRantagonist头颈肿瘤印度上市16AntegrennatalizumabElan人源化抗体α4β1integrinantagonist多发性硬化，克隆氏病2006美国等国17Avastinbevacizumab贝伐单抗Roche人源化抗体VEGFantagonist抗肿瘤2004美国等18GenentefalizumabRoche人源化抗体CD11aantagonist银屑病2004瑞士等19XolairomalizumabRoche人源化抗体Ig-Einhibitor哮喘2003美国等20Lucentisranibizumab雷尼珠单抗Roche人源化抗体VGFRantagonist老年湿性黄斑2006美国等21ActemratocilizumabRoche人源化抗体IL-6receptorantagonist类风湿，Castleman’sdisease05年日本上市22Herceptintrastuzumab曲妥珠单抗Roche人源化抗体EGFRantagonist乳腺癌1998美国等23CimziacertolizumabpegolUCB人源化抗体TNF-αantagonist克隆氏病2008美国等24Vectibixpanitumumab帕尼突单抗Amgen人源抗体EGFRantagonist直肠癌2006美国等25Humiraadalimumab阿达木单抗AstraZeneca人源抗体TNFantagonist类风湿，克隆氏病2003美国等26StelaraustekinumabJ&J人源抗体IL-12、L-23antagonist银屑病2008加拿大等27Embreletanercept依那西普Amgen融合蛋白TNFantagonist类风湿、银屑病等1998美国28NplateromiplostimAmgen融合蛋白Thrombopoietinagonist血小板减少性紫癜2008美国序号商品名英文名中文名研发公司类型作用靶点适应症上市国家及时间29AmevivealefaceptAstellas融合蛋白CD2antagonist银屑病2003美国30Zevalinibritumomabtiuxetan替依莫单抗BiogenIdec融合蛋白CD20、DNAantagonist非霍奇金淋巴瘤2002美国31OrenciaabataceptBMS融合蛋白CD80、CD86antagonist类风湿2006美国32Bexxar131I-tositumomabGlaxoSmithKline融合蛋白CD20、DNAantagonist非霍奇金淋巴瘤2003美国33TumourNecrosisTherapy,PeregPeregrinePharmaceuticals融合蛋白DNAantagonist肺癌2007中国上市34ArcalystrilonaceptRegeneron融合蛋白IL-1、IL-1bantagonist家族冷自主炎症综合征、穆-韦二氏综合征2008美国35MylotarggemtuzumabWyeth单抗偶联物DNAantagonist非霍奇金淋巴瘤2000美国全球在研治疗性单克隆抗体临床III期以上的品种列表序号英文名研发公司类型作用靶点适应症所处阶段1inolimomabEUSAPharma鼠源抗体IL-2receptorantagonist抗排斥PhaseIII2abagovomabMenarini鼠源抗体未知卵巢癌PhaseIII3galiximabBiogenIdec人鼠嵌合抗体CD80antagonist非霍奇金淋巴瘤PhaseIII4lumiliximabBiogenIdec人鼠嵌合抗体CD23antagonist白血病PhaseIII5G-250J&J人鼠嵌合抗体CarbonicanhydraseIXinhibitor肾癌PhaseIII6pagibaximabSunolMolecular人鼠嵌合抗体Lipoteichoicacidantagonist感染PhaseIII7otelixizumabBTG人源化抗体CD3antagonistI型糖尿病PhaseIII8reslizumabCeptionTherapeutics人源化抗体IL-5antagonist食管炎PhaseIII9farletuzumabEisai人源化抗体Folatereceptorantagonist卵巢癌PhaseIII10solanezumabEliLilly人源化抗体βamyloidproteinantagonist老年痴呆PhaseIII11afutuzumabRoche人源化抗体CD20antagonist非霍奇金淋巴瘤PhaseIII12ocrelizumabRoche人源化抗体CD20antagonist类风湿、狼疮肾炎PhaseIII13pertuzumabRoche人源化抗体EGFRantagonist乳腺癌PhaseIII14epratuzumabImmunomedics人源化抗体CD22antagonist红斑狼疮PhaseIII15teplizumabMacroGenics人源化抗体CD3antagonistI型糖尿病PhaseIII16tanezumabPfizer人源化抗体NGFantagonist痛疼PhaseIII17vedolizumabTakeda人源化抗体α4β7integrinantagonist结肠炎，克隆氏病PhaseIII18bapineuzumabWyeth人源化抗体βamyloidproteinantagonist老年痴呆PhaseIII19motavizumabAstraZeneca人源化抗体immunostimulant抗感染Pre-registration20mepolizumabGlaxoSmithKline人源化抗体IL-5antagonist高嗜酸性粒细胞综合症Pre-registration序号英文名研发公司类型作用靶点适应症所处阶段21briakinumabAbbott人源抗体IL-12、IL-23antagonist银屑病PhaseIII22ramucirumabEliLilly人源抗体EGFRkinaseinhibitor乳腺癌PhaseIII23zalutumumabGenmab人源抗体EGFRantagonist头颈癌PhaseIII24belimumabHumanGenomeSciences人源抗体Bcellactivatingfactorinhibitor红斑狼疮PhaseIII25ipilimumabMedarex人源抗体CTLA4inhibitor黑色素瘤、前列腺癌PhaseIII26efungumabNovartis人源抗体热休克蛋白90抗感染PhaseIII27figitumumabPfizer人源抗体Insulin-likegrowthfactor1antagonist非小细胞肺癌PhaseIII28denosumabAmgen人源抗体Osteoclastinhibitor骨质疏松Pre-registration29raxibacumabAstraZeneca人源抗体Banthracisprotectiveantigeninhibitor抗感染Pre-registration30ofatumumabGenmab人源抗体CD20antagonist白血病Pre-registration31golimumabJ&J人源抗体TNF-αantagonist银屑病关节炎Registered32canakinumabNovartis人源抗体IL-1bantagonist家族冷自主炎症综合征、穆-韦二氏综合征Registered33naptumomabestafenatoxActiveBiotech融合蛋白Immunostimulant肾癌PhaseIII34NeuradiabBradmerPharmaceuticals融合蛋白Tenascinantagonist脑癌PhaseIII35belataceptBMS融合蛋白CD28antagonist抗移植排斥PhaseIII36chTNT-1/BPeregrinePharmaceuticals融合蛋白HistoneH1inhibitor脑癌PhaseIII37afliberceptRegeneron融合蛋白VEGFantagonist多种实体瘤PhaseIII序号英文名研发公司类型作用靶点适应症所处阶段38VEGFTrap-EyeRegeneron融合蛋白VEGFantagonist老年湿性黄斑病变PhaseIII39ataciceptZymoGenetics融合蛋白Bcellactivatingfactorinhibitor狼疮肾炎,红斑狼疮PhaseIII40Trastuzumab-DM1Roche单抗偶联体EGFR-2antagonist乳腺癌PhaseIII41inotuzumabWyeth单抗偶联体CD22antagonist非霍奇金淋巴瘤PhaseIII