2012-综述-2012张国庆 新型肿瘤增殖标志-血清胸苷激酶1的临床应用

1【】【】R730．231+．1【】ADOI10．3969/j．issn．1672－4992．2012．08．74【】1672－4992－201208－1743－03thymidinekinaseTKdeoxythymidinedTdRdeoxythymidylicmonophosphatedTMP。60DNATdRTMP。1958－1960TK。TK。TK1TK21。TK1DNAS。TK1G1S。G1TK1SG22。TK1TK1。TK1TK1。1serumthymidinekinase1S－TK1、3－5。1S－TK1“”①②③。Xu6/S－TK1ROC0．978+ROC0．941S－TK1。Chen711278S－TK1【】2012－02－03【】2012－02－29【】2009BAI86B05【】100853【】1979－。[e-mail]【】1962－、。[e-mail]－TK1S－TK1＞2pM0．5%83%、、、、、。88869S－TK11S－TK15．78%85．2%。S－TK1。、、、7．8%3．9%P＜0．05。S－TK1/S－TK1。、。83%。S－TK1。2S－TK1LiHX9ELC250nonsmallcelllungcancerNSCLCS－TK1。250NSCLC188M062M116。NSCLCS－TK1P＜0．0001M0T2S－TK1T1P=0．042T3－T4T1－T2P=0．01ⅠⅡS－TK1P=0．057ⅢⅠ－ⅡS－TK1P=0．0251S－TK145%n=38P＜0．001。M1、S－TK11S－TK1。NSCLCS－TK1。LiZS10101、39157NSCLCS－TK1S－TK1P=0．021P＜0．005·3471·20128208MODERNONCOLOGYAug.2012VOL.20NO.08。NSCLCS－TK1P=0．006、P=0．001P=0．035。2．5。S－TK1。S－TK154%I－IIS－TK12pMS－TK11pM。ZhangJ11ELC561、1、36S－TK1。S－TK1Ⅰ－Ⅲ、T1－T2G1－G4S－TK1S－TK1166%16。S－TK1。1S－TK1。LiZ1225NSCLC、124S－TK11S－TK1、、。S－TK111S－TK1。1－3、CT、MRIELC1－3S－TK1。3TK1KrederNC13SW－1573XTK1TK261．5224。TKX。HeQ14X0．01GyTKX1GyTK。TKX0．1Gy。TK1TK1a0．5－1GyX50%。TK1TK1bTK1a。TK1TK1aTK1b241－5Gy12TK124。、XTK1TK1X。HeQ15TK1XdTTP。dTTPTK1。TK1S－TK1。4TKPanZL1637、1d、4S－TK1。TK1P＜0．0011dS－TK14S－TK1。S－TK1CRS－TK1PRNR。1dS－TK1①TK1TK1②TK1S－TK1③TTK1。4S－TK1①②ATPDNA。CRNRP＜0．001PRNRS－TK1P＜0．005S－TK1①CRS－TK1PRNRS－TK1②S－TK1。S－TK1。Xu6234、10、53、20761S－TK1ROC。S－TK13．1±2．3pMS－TK12．3±1．9pM1．4±0．8pM、1．1±0．8pM0．6±0．4pMS－TK1P＜0．01。、S－TK1S－TK1。ChenYan17S－TK1、、、/。。。5S－TK14P＜0．01。。I－ⅢⅣ。I－ⅢS－TK137%P=0．123ⅣS－TK183%P＜0．001S－TK1S－TK1P=0．088。S－TK145%S－TK171%P＜0．01。S－TK1·4471·1P=0．114。S－TK163%P＜0．001S－TK1。ChenY17S－TK1。40、11CR、PR、SD、PDS－TK1。70%S－TK1。SDPDS－TK1＞2pMCRPRS－TK1＜2pM。ChenY17S－TK1S－TK1。5S－TK1。S－TK1ROC6。S－TK12pM。S－TK1。S－TK1、、S－TK1NSCLC、17。NSCLCS－TK1。S－TK1ROC。ROCROC、、、、、、、。S－TK1。【】1GronowitzSJKallanderCFRDiderholmHetal．Applicationofaninvitroassayserumthymidinekinaseresultsonviraldiseaseandmalig-nanciesinhumansJ．IntJCancer19843315－12．2SherleyJLKellyTJ．Regulationofhumanthymidinekinasedur-ingthecellcycleJ．JBiolChem19882638350－8358．3HeQZouLZhangPAetal．Theclinicalsignificanceofthymidinekinase1measurementinserumofbreastcancerpatientsusinganti－TK1antibodyJ．IntJBiolMarkers200015139－146．4HeQFornanderTJohanssonHetal．Thymidinekinase1inserumpredictsincreasedriskofdistantorloco－regionalrecur-rencefollowingsurgeryinpatientswithearlybreastcancerJ．AnticancerRes2006264753－4759．5TopolcanOHolubecJrL．TheroleofthymidinekinaseincancerdiseasesJ．ExpertOpinMedDiagn20082129－141．6XuXHZhangYMShuXHetal．Serologicalthymidinekinase1reflectsprogressionofpre－malignantandmalignanttumoursdur-ingtherapyJ．MolMedRep20081705－712．7ChenZHZhouHTianNBetal．Serologicalthymidinekinase1S－TK1indicatesanelevatedriskfordevelopmentofmalignanttumoursJ．AnticancerRes200863897－3907．8．1S－TK1－8869J．20104135－38．9LiHXLeiDSWangXQetal．Serumthymidinekinase1isaprognosticandmonitoringfactorinpatientswithnon－smallcelllungcancerJ．OncolRep2005131145－149．10LiZSWangYHHeJetal．Serologicalthymidinekinase1isaprognosticfactorinesophaguscardialandlungcarcinomasJ．EurJCancerPrev2010194313－318．11ZhangJJiaQZouSetal．Thymidinekinase1aproliferationmarkerfordeterminingprognosisandmonitoringthesurgicalout-comeofprimarybladdercarcinomapatientsJ．OncolRep2006152455－461．12LiZWangYMaJetal．Transientincreaseinserumthymi-dinekinase1withinoneweekaftersurgeryofpatientswithcarci-nomaJ．AnticancerRes20103041295－1299．13KrederNCvanBreeCPetersGJetal．Enhancedlevelsofde-oxycytidinekinaseandthymidinekinase1and2afterpulsedlowdoserateirradiationasanadaptiveresponsetoradiationJ．On-colRep200291141－144．14HeQSkogSWelanderIetal．X－irradiationeffectsonthy-midinekinaseTKTK1and2innormalandmalignantcellsJ．CellProlif200235269－81．15HeQSkogSWelanderIetal．X－irradiationeffectsonthy-midinekinaseTKII．ThesignificanceofdeoxythymidinetriphosphateforinhibitionofTK1activityJ．CellProlif200235283－92．16PanZLJiXYShiYMetal．Serumthymidinekinase1con-centrationasaprognosticfactorofchemotherapy－treatednon－Hodgkin＇slymphomapatientsJ．JCancerResClinOncol201013681193－1199．17ChenYYingMChenYetal．Serumthymidinekinase1cor-relatestoclinicalstagesandclinicalreactionsandmonitorstheoutcomeoftherapyof1247cancerpatientsinroutineclinicalset-tingsJ．IntJClinOncol2010154359－368．·5471·20128208MODERNONCOLOGYAug.2012VOL.20NO.08