withhypoxicischaemicencephalopathy-metaanaly

Coolingfornewbornswithhypoxicischaemicencephalopathy(Review)JacobsSE,HuntR,Tarnow-MordiWO,InderTE,DavisPGThisisareprintofaCochranereview,preparedandmaintainedbyTheCochraneCollaborationandpublishedinTheCochraneLibrary2007,Issue4(Review)Copyright©2008TheCochraneCollaboration.PublishedbyJohnWiley&Sons,Ltd.TABLEOFCONTENTS1HEADER.......................................1ABSTRACT......................................2PLAINLANGUAGESUMMARY..............................2BACKGROUND....................................3OBJECTIVES.....................................4METHODS......................................5RESULTS.......................................11DISCUSSION.....................................12AUTHORS’CONCLUSIONS...............................12ACKNOWLEDGEMENTS................................13REFERENCES.....................................15CHARACTERISTICSOFSTUDIES.............................25DATAANDANALYSES..................................Analysis1.1.Comparison1Therapeutichypothermiaversusstandardcare,Outcome1Deathormajordisabilityinsurvivorsassessed,byqualityoffollow-up.........................28Analysis1.2.Comparison1Therapeutichypothermiaversusstandardcare,Outcome2Deathormajordisabilityinsurvivorsassessed,bymethodofcooling.........................29Analysis1.3.Comparison1Therapeutichypothermiaversusstandardcare,Outcome3Mortality,bymethodofcooling.30Analysis1.4.Comparison1Therapeutichypothermiaversusstandardcare,Outcome4Majorneurodevelopmentaldisability,byqualityoffollow-up............................31Analysis1.5.Comparison1Therapeutichypothermiaversusstandardcare,Outcome5Majorneurodevelopmentaldisabilityinsurvivorsassessed,byqualityoffollow-up.....................32Analysis1.6.Comparison1Therapeutichypothermiaversusstandardcare,Outcome6Majorneurodevelopmentaldisabilityinsurvivorsassessed,bymethodofcooling.....................33Analysis1.7.Comparison1Therapeutichypothermiaversusstandardcare,Outcome7Cerebralpalsyinsurvivorsassessed,bymethodofcooling................................34Analysis1.8.Comparison1Therapeutichypothermiaversusstandardcare,Outcome8Neuromotordelay(BSIDPDImorethan2SDbelowmean)insurvivorsassessed,byqualityoffollow-up.............35Analysis1.9.Comparison1Therapeutichypothermiaversusstandardcare,Outcome9Neuromotordelay(BSIDPDImorethan2SDbelowmean)insurvivorsassessed,bymethodofcooling..............36Analysis1.10.Comparison1Therapeutichypothermiaversusstandardcare,Outcome10Neuromotordevelopment(BSIDPDI)insurvivorsassessed..............................37Analysis1.11.Comparison1Therapeutichypothermiaversusstandardcare,Outcome11Developmentaldelay(BSIDMDImorethan2SDbelowmean)insurvivorsassessed,byqualityoffollow-up...........38Analysis1.12.Comparison1Therapeutichypothermiaversusstandardcare,Outcome12Developmentaldelay(BSIDMDImorethan2SDbelowmean)insurvivorsassessed,bymethodofcooling............39Analysis1.13.Comparison1Therapeutichypothermiaversusstandardcare,Outcome13Mentaldevelopment(BSIDMDI)insurvivorsassessed..............................40Analysis1.14.Comparison1Therapeutichypothermiaversusstandardcare,Outcome14Blindnessinsurvivorsassessed,bymethodofcooling................................41Analysis1.15.Comparison1Therapeutichypothermiaversusstandardcare,Outcome15Deafnessinsurvivorsassessed,bymethodofcooling................................42Analysis1.16.Comparison1Therapeutichypothermiaversusstandardcare,Outcome16Sinusbradycardia....43Analysis1.17.Comparison1Therapeutichypothermiaversusstandardcare,Outcome17Hypotensionrequiringinotropicsupport.....................................44Analysis1.18.Comparison1Therapeutichypothermiaversusstandardcare,Outcome18Arrhythmiarequiringmedicaltreatment....................................45Analysis1.19.Comparison1Therapeutichypothermiaversusstandardcare,Outcome19Anaemiarequirningtransfusion...................................46Analysis1.20.Comparison1Therapeutichypothermiaversusstandardcare,Outcome20Leukopaenia......46Analysis1.21.Comparison1Therapeutichypothermiaversusstandardcare,Outcome21Thrombocytopaenia...47iCoolingfornewbornswithhypoxicischaemicencephalopathy(Review)Copyright©2008TheCochraneCollaboration.PublishedbyJohnWiley&Sons,Ltd.Analysis1.22.Comparison1Therapeutichypothermiaversusstandardcare,Outcome22Coagulopathyresultinginmajorthrombosisorhaemorrhage..............................48Analysis1.23.Comparison1Therapeutichypothermiaversusstandardcare,Outcome23Hypoglycaemia.....49Analysis1.24.Comparison1Therapeutichypothermiaversusstandardcare,Outcome24Hypokalaemia.....49Analysis1.25.Comparison1Therapeutichypothermiaversusstandardcare,Outcome25Oliguria.......50Analysis1.26.Comparison1Therapeutichypothermiaversusstandardcare,Outcome26Sepsis........51Analysis1.27.Comparison1Therapeutichypothermiaversusstandardcare,Outcome27Seizures.......52Analysis2.1.Comparison2Therapeutichypothermiaversusstandardcareininfantswithsevereencephalopathy,Outcome1Deathormajordisability