HBsAg阳性B超诊断的脂肪肝(男性人群)丙氨酸氨基转

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2009259:(:30671873):510515,(,,,,),():E-mail:wensj@fimmu.comHBsAg10%,(HBV)。,B(sonographicfattyliver,SFL)[1]。,,HBVSFL,[2],HBsAgB():HBsAg、B(SFL)。:20066-9(18~70,,),、、、、、、HBVB。:HBsAgSFL(HBsAg+/SFL+)2.24%(100/4469);HBsAgSFLHBsAg[18.3%(100/547)vs24.0%(943/3922),P=0.003]。3224,HBsAgSFL(HBsAg+/SFL+,n=94)HBsAgSFL(HBsAg-/SFL+,n=837)>35、>25、、ALT[(ULN),40U/L],HBsAgSFL(HBsAg+/SFL-,n=318HBsAg-/SFL-,n=1975)。HBsAg+/SFL-(OR=4.453,95%CI=2.921~6.787,P<0.001)HBsAg-/SFL+(OR=4.395,95%CI=3.127~6.178,P<0.001),ALT>1.5ULNHBsAg+/SFL+(OR=6.381,95%CI=3.619-11.250,P<0.001)。ALT≤1.0ULN(n=2512),ALT>0.5ULNHBsAg+/SFL+(44/51)HBsAg-/SFL+(356/487,P=0.043)HBsAg+/SFL-(157/223,P=0.022)HBsAg-/SFL-(844/1751,P<0.001)。:HBsAgBSFLHBVHBsAgSFL,。;B;;DistributionofalaninetransarninaseinmalesubjectswithultrasonographydiagnosticfattyliverandpositiveserumHBsAgCHENJin-jun觹,YANGJie,GENGShu-ying,WANGYan-jun,HOUJin-lin,WENShu-juan.觹HepatologyUnitandDepartmentofInfectiousDiseases,NanfangHospital,SouthernMedicalUniversity,Guangzhou510515,ChinaCorrespondingauthor:WENShu-juanE-mail:wensj@fimmu.com【Abstract】ObjectiveToinvestigatetheclinicalcharacteristicsofserumHBsAgpositivesubjectswithultrasonographydiagnosticfattyliver(SFL).MethodsGender,age,height,bodyweight,bloodpressure,fastingbiochemicalcriterions,serumHBVmarkers,andabdominalsonographicevaluationdatainallsubjects(aged18-70,withoutseverediseases)fromJunetoSeptember2006werecollectedandanalyzed.ResultsPrevalenceofHBsAgpositiveSFL(HBsAg+/SFL+)was2.24%(100/4469),andtheoccurrencerateofSFLwaslowerinHBsAgcarriers(n=547)thanthatinsubjectswithoutHBsAg(n=3922)(18.3%vs24.0%,P=0.003).Proportionsofsubjectswithage>35,bodymassindex>25,elevatedplasmaglucose,elevatedcholesterolandelevatedalaninetransarninase(ALT)(>40IU/L)inHBsAgpositiveSFLgroup(HBsAg+/SFL+group,n=94)weresimilartothoseinHBsAgnegativeSFLgroup(HBsAg-/SFL+group,n=837),butthoseinthebothgroupsweresignificantlyhigherthanthoseinnoSFLgroups(HBsAg+/SFL-group,n=318andHBsAg-/SFL-group,n=1975).SubjectsinHBsAg+/SFL+grouphadahigherriskhavingALT>60IU/L(OR=6.381,95%CI=3.619-11.250,P<0.001)ascomparedtoHBsAg-/SFL+group(OR=4.395,95%CI=3.127-6.178,P<0.001)orHBsAg+/SFL-group(OR=4.453,95%CI=2.921-6.787,P<0.001).InsubjectswithnormalALT(≤40IU/L)levels,proportionofsubjectswithactualALT>20IU/LwassignificantlyhigherinHBsAg+/SFL+group(44/51)thanthoseinHBsAg-/SFL+group(356/487,P=0.043),HBsAg+/SFL-group(157/223,P=0.022)andHBsAg-/SFL-group(844/1751,P<0.001).ConclusionsTheclinicalcharacteristicsofmaleHBsAgcarrierswithSFLweredifferentfromthosewithordinaryHBVinfection,butweresimilartoSFLpatientswithoutHBsAg.TheprobabilityofexacerbationisincreasedinHBsAgcarrierswithSFLthanthatinSFLpatientswithoutHBsAg.【Keywords】Fattyliver;Bultrasonograpgy;HepatitisBsurfaceantigen;Alanineaminotransferase13872009259。,HBsAgSFL[3]。HBsAgSFL,SFL?[(ALT)]。11.120069-12。:(1)18~70,;(2);(3)、、、[、、、ALT、(AST)]、HBsAgB。1.21.2.1SFLB,。SFL《》BSFL[4]。1.2.2。ALTAST(ULN)40U/L,ULN6.1mmol/L,ULN1.7mmol/L,ULN5.7mmol/L,(HDL)0.92mmol/L,(LDL)ULN3.36mmol/L,(VLDL)ULN1.3mmol/L。>135mmHg()>85mmHg。HBsAg。(kg)/2(m2),25。1.3Fisher,t;Logistic();。SPSS10.0,P<0.05。22.1HBsAg+/SFL+SFL()HBsAg,4:HBsAgSFL(HBsAg+/SFL+)、HBsAgSFL(HBsAg-/SFL+)、HBsAgSFL(HBsAg+/SFL-)HBsAgSFL(HBsAg-/SFL-)。4469(3324),HBsAg+/SFL+100(94,94.0%)、HBsAg-/SFL+943(837,88.8%)、HBsAg+/SFL-447(318,71.7%)HBsAg-/SFL-2979(1975,66.3%)。HBsAg+/SFL+2.24%(100/4469);HBsAgSFLHBsAg(18.3%vs24.0%,P=0.003)。4(P<0.001)HBsAg+/SFL+(6),。2.2HBsAg+/SFL+HBsAg-/SFL+,HBsAg+/SFL+(35)、(>25)、、ALT11.5ULN(1)。HBsAg-/SFL+HBsAg+/SFL+,AST(P<0.05)。,HBsAg-/SFL+HDLLDLHBsAg+/SFL-HBsAg-/SFL-,(1)。2.3HBsAg+/SFL+ALT1(%)()(mmol/L)(mmol/L)(mmol/L)HDL(mmol/L)LDL(mmol/L)VLDL(mmol/L)AST(U/L)ALT(U/L)ALT(U/L)>35>25>6.1>1.7>5.7<0.92>3.36>1.35>40>40>60(n=3224)1600(49.6)1102(34.2)806(25.0)153(4.7)1025(31.8)877(27.2)100(3.1)521(16.2)695(21.6)300(9.3)685(21.2)269(8.3)SFL-/HBsAg-G1(n=1975)876(44.4)435(22.0)394(19.9)51(2.6)429(21.7)422(21.4)47(2.4)277(14.0)265(13.4)94(4.8)213(10.8)66(3.3)SFL+/HBsAg-G2(n=837)515(61.5)550(65.7)332(39.7)82(9.8)508(60.7)353(42.2)45(5.4)181(21.6)370(44.2)136(16.2)334(39.9)143(17.1)SFL-/HBsAg+G3(n=318)156(49.1)55(17.3)53(16.7)11(3.5)49(15.4)69(21.7)5(1.6)45(14.2)28(8.8)46(14.5)95(29.9)39(12.3)SFL+/HBsAg+G4(n=94)53(56.4)62(66.0)27(28.7)9(9.6)41(43.6)33(35.1)3(3.2)18(19.1)32(34.0)24(25.5)43(45.7)21(22.3)G4vsG10.026<0.0010.0480.001<0.0010.0030.4950.174<0.001<0.001<0.001<0.001G4vsG20.3721.0000.0441.0000.0020.1870.4670.6910.0620.0310.3770.256G4vsG30.241<0.0010.0120.025<0.0010.0100.3900.254<0.0010.0180.0060.020P13882009259ALT11.5ULN21.2%(685/3224)8.3%(269/3224)。,LogisticALT(>1.0ULN1.5ULN)。sAg+/SFL+ALT>1.0ULN>1.5ULN(2),sAg-/SFL+sAg+/SFL-。25、VLDL>35ALT>1.0ULN>1.5ULN(2)。2.4ALTsAg+/SFL+ALTALTsAg+/SFL+ALT28.5U/L,sAg+/SFL-sAg-/SFL-,sAg-/SFL+(P=0.080)。sAg+/SFL+ALT>0.5ULN(86.3%)3(3),ALT>0.75ULNHBsAg-/SFL-,HBsAg-/SFL+HBsAg+/SFL-(3)。2ALT11.5()(mmol/L)VLDL(mmol/L)HDL(mmol/L)≤35>35SFL-/HBsAg-SFL+/HBsAg-SFL-/HBsAg+SFL+/HBsAg+≤25>25≤5.7>5.7≤1.3>1.3≥0.92<0.92OR1.01.3441.03.8023.8445.1771.01.6501.01.2911.01.7161.01.7411.01.24895%CI1.110~1.6273.039~4.75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