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年产160吨芬布芬工艺设计目录摘要...................................................................................................................................................21引言............................................................................................................................................42概述..........................................................................................................................................52.1设计依据....................................................................................................................52.2产品概述..................................................................................................................................53缩合工段物料衡算............................................................................................................73.1设计任务...............................................................................................................................73.2缩合水解反应式...................................................................................................................73.3缩合水解过程各物料消耗...................................................................................................73.4原料质量标准和配比...........................................................................................................73.5缩合反应罐进料以及出料...................................................................................................84缩合工段能量衡算...............................................................................................................104.1缩合反应能量能量衡算相关数据.....................................................................................104.2各物质的比热计算.............................................................................................................114.3熔解热计算.........................................................................................................................114.4热量计算.............................................................................................................................114.5过程热效应.........................................................................................................................115缩合工段设备选型..............................................................................................................136劳动组织与岗位定员..........................................................................................................166.1劳动组织..............................................................................................................................166.2劳动保障与安全生产.............................................................................................................166.3“三废”处理及综合利用..........................................................................................................187论文小结.................................................................................................................................19附：1.参考文献2.附图年产150吨芬布芬工艺设计王玲玲[摘要]本次设计为年产160吨芬布芬的车间工艺设计。芬布芬，又名联苯丁酮酸；苯酮酸。为一较新型的长效非甾体消炎镇痛药。本设计所采用的工艺路线为：以联苯、丁二酸酐和三氯化铝为原料，加入二氯乙烷缩合后经由盐酸和水水解获得芬布芬。年产芬布芬160吨，缩合水解工段收率93.25%，精制工段收率94.94%，单程收率88.53%，总收率92.51%，回收率4.3%。成品质量标准：芬布芬纯品99%杂质及水的含量1%。设计内容主要包括芬布芬车间工艺设计依据，工艺路线论证，工艺流程设计，全流程物料衡算，能量衡算，工艺设备选型与计算，车间布置设计，工程经济，劳动保护，安全生产与“三废”处理及其综合利用等内容。设计所得成果主要有设计说明书和相应的图，其图包括车间设备平、立面布置图、带控制点的工艺流程图、物料流程框图、精烘包车间平面布置图、典型设备的装备图、典型工段配管图。[关键词]芬布芬车间工艺设计工艺路线收率[Abstract]Thedesignfortheannualoutputof160tonsoffenbufenintheworkshopprocessdesign.Fenbufen,alsoknownasDingketoacidbiphenyl;benzeneketoacid.Forthenewerlong-actingnon-steroidalanti-inflammatoryanalgesics.Thedesignprocessusedroutesare:tobiphenyl,succinicanhydrideandaluminumchlorideastherawmaterial,ethylenedichloridecondensationandwaterafterhydrolysisbyhydrochloricacidtoobtainfenbufen.Designelementsincludefenbufenworkshopprocessdesignbasis,processroutefeasibilitystudies,processdesign,thewholeprocessmaterialbalance,energybalance,processequipmentselectionandcalculation,plantlayoutdesign,engineering,economic,laborprotection,safetyandthreewastesandthecomprehensiveutilizationofcontents.Designfromspecificationanddesignofthemainresultsofthecorrespondinggraph,thegraphincludingworkshopequipment,flat,verticalsurfacelayout,withaflowchartofthecontrolpoint,thematerialflowdiagram,finishing,drying,packingworkshopfloorplan,typicalequipmentandequipmentmapSectionoftypicalpipingdiagram.[Keywords]fenbufenshopprocessdesignprocessroutetheyield1引言芬布芬，又名联苯丁酮酸，属解热镇痛及非甾体抗炎镇痛药。用于类风湿性关节炎、风湿性关节炎、骨关节炎、强直性脊椎炎及痛风等的治疗。亦用于牙痛、手术后疼痛、外伤疼痛等的止痛。其合成工艺在不断地改进，日益完善。基于实习所获，同时结合专业课的深入学习及老师的悉心教导，我开展了对芬布芬的车间工艺设计。本次设计内容以对联苯、丁二酸酐和三氯化铝为原料经过缩合反应，得到中间后，再经过水解最后经过环合、回收、精制等工序，得到了芬布芬。由此工艺可知,芬布芬的工艺很复杂，因此设计的任务非常庞大。这不仅要求我们要有扎实的专业理论知识，更要有灵敏的理解感悟的实验能力，熟练运用画图工具，其成果包括了工艺流程设计、物料衡算、能量衡算、工艺设备选型计算、车间布置设计、典型设备的装配、设计说明书的撰写、查阅英文并翻译、绘制相应的工艺图。本设计为初步设计，我按照设计任务书所要求内容，一步一步完成，但由于经验不足，理论和实践知识不够扎实，在设计中还存在大量不足之处，诚请老师给予指出和修正。2概述1设计依据盐城师范学院制药工程专业毕业设计任务书。设计遵循的技术法规（1）《药品生产质量管理规范实施指南》（2001年版，中国化学制药工业协会，中国医药工业公司）；（2）《工业企业噪声控制设计规范》GBJ87-85；（3）《环境空气质量标准》GB3095-1996；（4）《污水综合排放标准》GB8978-1996；（5）