蓝莓及其提取物保健功效的研究进展_王莹

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王莹王鸿蔡东联200433、130021461blueberryericaceaevaccinium.spp。20、、、、1。、、、、、2。、、、、、、、、、、1。1、、、、5、、、、、、、、、、、、、、、、、、、、、、、、、、、、、、、、、、、、E、、、ω-3、、、1.。3。tBHPtert-butylhydroperox-ide4。2.、。、。。fischier-3442%。·081···JMedResJul2013Vol.42No.75。/oxidative/inflammatoryMAPKPKC-gammaCREB6。vacciniip38/JNKMEK1/2ERK1/27。。3.。48350g8。NO8。2%1222%9。1%20E39%58%E10。4.。、、-S-DNA。11。。CYP7A1CYP5112。5.、。、、、、、、、、13。Fisher-34414。、。、、。HT-29Caco-2。HL60/VINCHL60/DOX15。6.、、、、。16。IL-1、TNF-α、NF-κBmRNA17。HCVNS-318。7.16、19。Vaccinii。12C16。1、2。2C57BL/6J0.2mg/ml·181·20137427··20。3。5%100mRNAⅠ。8.。。。2、、、、、。-BROSp53DNA。、。、2。。。、。1.J.20108215-2172DutotM.Oxidativestressmodulationusingpolyphenol-richblueber-riesapplicationonahumanretinalcellmodelJ.JFrOphtalmol20083110975-9803PapandreouMA.Effectofapolyphenol-richwildblueberryextractoncognitiveperformanceofmicebrainantioxidantmarkersandacetylcho-linesteraseactivityJ.BehavBrainRes20091982352-3584JosephJA.DifferentialprotectionamongfractionatedblueberrypolyphenolicfamiliesagainstDA-Abeta42-andLPS-induceddecrementsinCa2+bufferinginprimaryhippocampalcellsJ.JAgricFoodChem201058148196-82045VuongT.Biotransformedblueberryjuiceprotectsneuronsfromhydro-genperoxide-inducedoxidativestressandmitogen-activatedproteinkinasepathwayalterationsJ.BrJNutr20101045656-6636BasuA.BlueberriesdecreasecardiovascularriskfactorsinobesemenandwomenwithmetabolicsyndromeJ.JNutr201014091582-15877KaleaAZ.DietaryenrichmentwithwildblueberriesVacciniumangusti-foliumaffectsthevascularreactivityintheaortaofyoungspontaneouslyhypertensiveratsJ.JNutrBiochem201021114-228KaleaAZ.VascularreactivityisaffectedbydietaryconsumptionofwildblueberriesintheSprague-DawleyratJ.JMedFood200912121-289AhmetI.Survivalandcardioprotectivebenefitsoflong-termblueber-ryenricheddietindilatedcardiomyopathyfollowingmyocardialinfarctioninratsJ.PLoSOne2009411797510WuX.DietaryblueberriesattenuateatherosclerosisinapolipoproteinE-deficientmicebyupregulatingantioxidantenzymeexpressionJ.JNutr201014091628-163211WangYP.EffectsofblueberryonhepaticfibrosisandtranscriptionfactorNrf2inratsJ.WorldJGastroenterol201016212657-266312KimH.Hepaticgeneexpressionrelatedtolowerplasmacholesterolinhamstersfedhigh-fatdietssupplementedwithblueberrypeelsandpeelextractJ.JAgricFoodChem20105873984-399113OsmanNAdawiDAhrneSetal.Probioticsandblueberryattenu-atetheseverityofdextransulfatesodiumDSS-inducedcolitisJ.DigDisSci2008532464-427314TakeshitaM.Proanthocyanidinfromblueberryleavessuppressesex-pressionofsubgenomichepatitisCvirusRNAJ.JBiolChem20092843221165-2117615StullAJ.Bioactivesinblueberriesimproveinsulinsensitivityinobeseinsulin-resistantmenandwomenJ.JNutr2010140101764-176816VuongT.Antiobesityandantidiabeticeffectsofbiotransformedblue-berryjuiceinKKAymiceJ.IntJObesLond200933101166-117317Nemes-NagyE.Effectofadietarysupplementcontainingblueberryandseabuckthornconcentrateonantioxidantcapacityintype1diabeticchildrenJ.ActaPhysiolHung2008954383-39318PriorRL.Purifiedblueberryanthocyaninsandblueberryjuicealterdevelopmentofobesityinmicefedanobesogenichigh-fatdietJ.JAgricFoodChem20105873970-397619PriorRL.PurifiedberryanthocyaninsbutnotwholeberriesnormalizelipidparametersinmicefedanobesogenichighfatdietJ.MolNutrFoodRes200953111406-141820HurstRD.Blueberryfruitpolyphenolicssuppressoxidativestress-inducedskeletalmusclecelldamageinvitroJ.MolNutrFoodRes2010543353-3632013-01-062013-02-20·281···JMedResJul2013Vol.42No.7

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