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ChinJEvid-basedMed2012,12(11):1372-1378•1372•CJEBM©2012EditorialBoardofChinJEvid-basedMed*21311.610041)2.610041)3.643000PubMedEMbaseMEDLINEOvidCENTRALCBMCNKIRCT20122RevMan5.0Meta153 1798MetaRD=–0.0695%CI–0.10–0.03P0.05RD=–0.0295%CI–0.080.03P0.05RD=–0.0995%CI–0.15–0.03P0.05RD=–0.0595%CI–0.100.00P0.05MetaPreventativeEffectsofProbioticsforInfantileEczemaandAtopicEczema:ASystematicReviewWANGYu1,ZENGGuo1*,ZHUCai-rong2,HUANGLu-jiao1,LIUKe3,YULi11.DepartmentofNutritionandFoodHygiene,WestChinaSchoolofPublicHealth,SichuanUniversity,Chengdu610041,China;2.DepartmentofHealthStatistics,WestChinaSchoolofPublicHealth,SichuanUniversity,Chengdu610041,China;3.ZigongCenterforDiseaseControlandPrevention,Zigong643000,ChinaAbstractObjectiveTosystematicallyevaluatethepreventativeeffectofprobioticsforinfantileeczemaandat-opiceczema.MethodsDatabasesincludingPubMed,EMbase,MEDLINE(Ovid),CENTRAL,CBMandCNKIweresearchedfrominceptiontoFebruary2012,soastocollecttherandomizedcontrolledtrials(RCTs)onprobioticsinpre-ventinginfantileeczemaandatopiceczema.Tworeviewersindependentlyscreenedliteratureaccordingtotheinclusionandexclusioncriteria,extracteddata,evaluatedqualityandcross-checked.Thenthemeta-analysiswasconductedusingRevMan5.0software.ResultAtotalof15RCTsinvolving3179infantswereincluded.Theresultsofmeta-analyseson8highqualityRCTsshowedthat:theincidenceofinfantileeczemawaslowerintheprobioticsgroupthantheplacebogroup,withasignificantdifference(RD=–0.06,95%CI–0.10to–0.03,P0.05).Probioticshadnopreventativeeffectoninfantileatopiceczema(RD=–0.02,95%CI–0.08to0.03,P0.05),andhadpreventativeeffectsonbothhighriskpopu-lation(RD=–0.09,95%CI–0.15to–0.03,P0.05)andgeneralpopulation(RD=–0.05,95%CI–0.10to0.00,P0.05)ofinfantileeczema.ConclusionProbioticshavecertainpreventativeeffectsoninfantileeczema.Duetothedifferencesofprobioticsintheaspectssuchasprobioticstrain,dosage,treatmentcourse,etc.,itsspecificeffectsoninfantileeczemaandatopiceczemashouldbefurthertested.KeywordsProbiotic;Infantileeczema;Atopiceczema;Systematicreview;Meta-analysis;Randomizedcontrolledtrial1987Email:wangyu10241987@163.com*Email:zgmu2003@126.com[1-3][4,5]2012,12(11):13721378•1373•©2012•[6]11.11.1.1RCT1.1.2/1.1.31.1.40.35U/mL1.1.51.2PubMedEMbaseMEDLINEOvidCENTRALCBMCNKIRCT2012229eczemaatopiceczemainfanteczemaatopicdermatitisprobioticsbifidobacteriumlactobacillusCBM11.3[7]1.42CONSORT201051.5RevMan5.0MetaQI2α=0.1RD95%CIMetaMeta22.129315[8-22]3 179112.22121CBM#1[]:#2[]:#3[]:#4[]:#5[]:#6#5OR#4OR#3OR#2OR#1#7[]:#8[]:#9[]:#10#9OR#8OR#7#11[]:#12[]:#13[]:#14[]:#15#13OR#12OR#11#16[]:#17[]:#18#17OR#16#19#18AND#15AND#10#20#19AND#6ChinJEvid-basedMed2012,12(11):1372-1378•1374•CJEBM©2012EditorialBoardofChinJEvid-basedMed[8-12,14,16,18-22][8,11-21]046%5[8,11,14,19,21]6[9,10,12,18,20,22]1[16]7[8,11,13-15,19,21]4[12,17,18,20,22]1[16]211[9,11-16,18,19,21,22]4[8,10,17,20]12[8,9,11-16,18,19,21,22]3[10,17,20]22.3Meta2.3.1[16]CONSORTn=290n=3n=234n=129n=46n=15n=83n=3111T/C%T/CT/CWickens2008[8]144/1504.021/4014/27+6022UKWestCE2009[9]84/879.09/19–F19–4131Rautava2002[10]27/3035.84/14–+3–2Taylor2006[11]88/8714.038/3423/12+–01HanifinRajkaNiers2009[12]50/4820.027/3310/8++012HanifinRajkaKalliomäki2001[13]64/6817.0–15/31+602Kukkonen2006[14]461/469.1120/150–+++–2UK459/469.4–57/82Kopp2007[15]50/4410.0–14/12+362UKKim2009[16]33/3541.012/22–++361HanifinRajka31/2946.0–3/6Huurre2008[17]72/680–7/12+–1HanifinRajkaDotterud2010[18]138/133.029/489/10+3–2UKBoyle2010[19]108/115.235/4319/19+–1UKBöttcher2008[20]51/534.521/19–+012HanifinRa-jkaSeymour44/4320.0–8/10Abrahamsson2007[21]95/939.034/3213/21+012HanifinRa-jkaSeymourSoh2008[22]124/1213.027/30–+–01HanifinRa-jkaSeymourT/C/+2012,12(11):13721378•1375•©2012•[8,10,17,20]Meta8[9,11,12,14,18,19,21,22]P=0.43I2=0%MetaRD=–0.0295%CI–0.080.03P0.0538[11-15,18,19,21]P=0.02I2=56%MetaRD=–0.0695%CI–0.10–0.03P0.0542.3.2/94Meta5[11,12,14,19,21]P=0.49I2=0%3[9,18,22]P=0.36I2=1%MetaRD=–0.0595%CI–0.100.00P0.05RD=–0.0995%CI–0.15–0.03P0.0552.3.37[8-11,19-21]7[8,11,13,15,19-21]MetaRD=–0.0495%CI–0.110.03P0.052CONSORT2010Wickens2008[8]WestCE2009[9]Rautava2001[10]Taylor2006[11]Niers2009[12]Kalliomäki2001[13]Kukkonen2006[14]Kopp2007[15]Kim2009[16]Huurre2008[17]Dotterud2010[18]Boyle2010[19]Böttcher2008[20]Abrahamsson2007[21]Soh2008[22]–+2ChinJEvid-basedMed2012,12(11):1372-1378•1376•CJEBM©2012EditorialBoardofChinJEvid-basedMed=–0.0395%CI–0.120.06P0.055[12,14,16,18,22]5[12,14,16-18]MetaRD=–0.0795%CI–0.11–0.02RD=–0.0495%CI–0.08–0.012.3.4[8,10,17,20][9,10,13]Meta3[1]MetaLGG3Meta4Meta2012,12(11):13721378•1377•©2012•[24][25]SPTsIgE0.35U/mLsIgEIgE1512SPTsIgEsIgESPTsIgESPTSPTsIgE0.35U/mLMeta10%[11,13,18,19][13]15/MetaChinJEvid-basedMed2012,12(11):1372-1378•1378•CJEBM©2012EditorialBoardofChinJEvid-basedMed