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··2011－11－29188521000。。、、。pH、、。。0.9%4h。IncompatibilityofomeprazolesodiumforinjectionWANGShi-hongWANGXiu-zhongNo．188HospitalofPeople'sLiberationArmyChaozhou521000ChinaAbstractObjectiveToinvestigatetheincompatibilityofomeprazolesodiumforinjection．MethodsDo-mesticliteraturesofomeprazolesodiumforinjectioninrecentyearsweresummarizedandanalyzed．ResultsOme-prazolesodiumforinjectionwasincompatiblewithmanydrugs．Addingotherdrugsintoomeprazolesodiumforinjec-tioncouldresultinthechangeoftheexternalappearanceofsolution．ThepHvaluetemperatureandlightcouldaffectthestabilityofomeprazolesodiumforinjection．ConclusionOmeprazolesodiumforinjectionisincompatiblewithmanydrugs．Itshouldbeaddedinto0.9%NSinclinicalinfusionandtheinfusionshouldbefinishedwithin4h．KeywordsOmeprazoleIncompatibilityOmeprazole。。《》2010《》17。。15--2-4--35--2----1H-pKa4pH、、、。pH。pH8～104h。pH8pH1。25--2-4--35--2----1H-5--2-4--35--2----1H-5--2--1H-。34、、。22.140mg100mL0.9%5%。。5pH4.5～7.54h、、pH。5%4h6。7。40mg100mL5%、10%6h4h8。5%·163·2012156PracticalPharmacyAndClinicalRemedies2012Vol．15No．6DOI:10.14053/j.cnki.ppcr.2012.06.0274h、pH、9。1h24h10%10。2.2114℃8h、25℃6h、37℃2hpH5%。37℃2h。12。、、、13-17。2.30.9%5%B618。100mL0.9%C、ATPA、B1K419。20Ⅱ。2.421。8.5%15min22。、23-25。2.526pH7.62hpH6.2。27。28。、48h。29。30。2.631。5%6h、pH、、32。、pH、4h10%33。2.734、6h、pH5h95%。、35-36。5min37。5%38。33.12。EDTAEDTApH。、。。pHpH＞10pHEDTA。。3.2、。39pH。pH·263·2012156PracticalPharmacyAndClinicalRemedies2012Vol．15No．6pH。pH。3.3pH。pH。44.1。“”“”“”“”。4.2。。。1．J．2007104352-354．2．J．2005255576-578．3．J．2005258775-776．4．J．200828191722-1724．5．pHJ．201141B31-32．6．J．20088225339-5340．7．J．2009714192．8．5J．201017226-27．9．J．201120628-30．10．J．20071710650-651．11．J．2011301112-114．12．-J．2010232229．13．J．20091612A52．14．J．2006131053．15．J．2010169F0003．16．J．2008208841．17．J．201010327972．18．B6J．2008216987．19．J．200420212322-2323．20．ⅡJ．200945275．21．J．2005335625-626．22．8．5%J．20082251193．23．J．201026829．24．J．2008223C844．25．J．20101092030．26．1J．201019758．27．J．200943175．28．J．200924193．29．J．20081543．30．1J．20088297299．31．J．200815538．32．6J．201019101742-1743．33．J．2004442032．34．10J．2010185442-445．35．J．200815817．36．J．20085464．37．J．2008257780．38．J．20062082209．39．J．2009282262-263．·363·2012156PracticalPharmacyAndClinicalRemedies2012Vol．15No．6