胃肠外科发展的趋势

:200032,21,,(evidence2basedmedicine),,,,,,,,,,,,,,,2,(endoscopicmucosalresection,EMR),,EMR,,,(endoscopicsubmucosaldissection,ESD)EMR,ESD:,EMR20068ESD,300,,Johns2HopkinsKalloo2090,,,20057,(ASGE)(SAGES),(naturalorificetranslumenalendoscopicsurgery,NOTES),,20063NOTES,,,,,,,,7022008214FuBuWaiKe,Aug.2008,Vol.21,No.4,,,,20,(gastrointestinalstromaltumors,GISTs),C2kitkit,CD117STI571(,),,2001,Joensuu1STI571GIST:147GISTSTI571400mg/d600mg/d,53.7%,50%96%STI571FDA,GISTSTI571,GISTKITZ9001(,),GIST1(3%vs17%),2007,,1CRPR1,(SU011248,SUTENT)(PDGFRRETKIT),PDGFR2VEGFR22STI571GIST,,,,(VEGF)Bevacizumab(,Avastin)(EGFR)Cetuximab(,Erbitux),,,,,,,,,,,,,II,,Roux2en2Y(laparoscopicadjustablegastricbanding,LAGB),,2007,II,(laparoscopicsleevegastrectomy)Roux2en2Y51.4%62%,,1992,DavidSackett(evidence2basedmedicine),,:,,,,,,,,,,2h,,8022008214FuBuWaiKe,Aug.2008,Vol.21,No.4,,,,,,,,,,,,(:2008206230)JournalofHuazhongUniversityofScienceandTechnologyMedicalSciencesSCI2EJournalofHuazhongUniversityofScienceandTechnologyMedicalSciences(ISSN167220733)()(SCI2E),2007271JournalofHuazhongUniversityofScienceandTechnologyMedicalSciences1979,29,1986(IM)52005Springer,,1SCI2EJournalofHuazhongUniversityofScienceandTechnologyMedicalSciences,,:43003013JournalofHuazhongUniversityofScienceandTechnologyMedicalSciences,:027283692514,:0272836929279022008214FuBuWaiKe,Aug.2008,Vol.21,No.4