多巴胺的自聚-附着行为与膜表面功能化

313Vol.31No.320116MEMBRANESCIENCEANDTECHNOLOGYJun.2011多巴胺的自聚附着行为与膜表面功能化徐又一*,蒋金泓,朱利平,朱宝库(,,,310027):多巴胺(dopamine)是一种生物神经递质,在水溶液条件下,它能在溶解氧的作用下发生氧化交联反应,形成强力附着于固体材料表面的聚多巴胺复合薄层.基于多巴胺的这一特性,近年来膜技术研究者们通过多巴胺在固体基膜上的自聚复合,对膜进行表面改性,并以具有反应活性的聚多巴胺复合层为平台,对膜进行进一步的表面修饰,实现膜的功能化.文章论述了多巴胺在膜表面修饰与功能化方面的研究进展,应用领域包括超/微滤膜生物医用膜以及渗透汽化膜等.:多巴胺;多巴;儿茶酚衍生物;功能化;仿生;表面改性:TQ028.8:A:10078924(2011)03003207,.,,,,().,,.,.;..,.,,3,4(LDOPA,L)3,4(dopamine,),,[1-3].,,.,.1多巴胺的超强黏附行为及其原理,,[4].(musseladhesiveproteins,MAPs),,.,MAPsMfp5(mytilusfootprotein5),30%L15%(lysine),MAPs[3,5,6].L,L,Mfp:20101231:973(2009CB623402);(50803054);(Y4100204):(1945),,,,.*[e-mail]3:335,[2].,,.,,,(1)[7,8].,,,,[1,2].1Fig.1Schemefordopaminecrosslinkinginaqueoussolution2多巴胺自聚复合在表面改性及功能化方面的应用2.1,,.,(2).,,,,,.2Fig.2SchematicrepresentationforsurfacemodificationofsolidmaterialsbydopamineaqueoussolutionLee[2]2g/L(pH8.5),,24h50nm.Xi[9](PE)(PVDF)(PTFE),,.Ku[10]PEPTFE,MC3T3E1.Yu[11]304,.Li[12](PSF),PSF.Pan[13]PSF,PSF.Kang[14](AAO),AAO,AAO(3).Yu[15],,pH,(4).343031(a)(PDMS);(b)90180[14]3Fig.3Micropatterningofsuperhydrophobicsurfacesandwettingproperties2.2,,.,,,.(a)pH/;(b)pH[15]4Fig.4Thesuggestedstructureofpolydopamine2.2.1.,,(SH)(NH2)(NH)(Michaeladdition)(Schiffbasereaction),(5)[2].5Fig.5SurfacemodificationofmaterialsbydopaminecoatingandsubsequentimmobilizationoffunctionalmoleculesSHNH2,(selfassembledmonolayers,SAMs).[16]PTFE,CGREDVDY,PTFE.SHNH2NH[(PEG)],,[2,3,17].McCloskey[18]PVDFPSF(PA)PEG,(BSA),.Jiang[19]PE,,.2.2.2,.,,3:35,.Li[20],2(BIBB),(ATRP)(PAAc),pH(6).6ATRP[20]Fig.6SchematicillustrationoftheATRPofAAconpolydopaminefunctionalizednylonmembraneinaqueoussolutions2.2.3,.,,[1,2,4].Liao[21,22](PI),PI,PI.,.,[4,23].Ou[24]PEPTFE(PET),((NH4)2TiF6)(H3BO3),(NH4)2TiF6H3BO3(TiO2),TiO2(7),MC3T3.7TiO2[24]Fig.7AschematicviewoftheTiO2depositiononthepolymersubstratesmediatedbypolydopamine2.3,.(),[1,2].,,..Fan[25],ATRP,316L(8),3T3,.,().,,363031.Lee[26]PDMS,,/.Lee[27](PEI)(HA),(LayerbyLayerassembly,LbL)PEIHA,.Lee[28]PEG(9),PEG,.2.4,.,,,,LbL.Bernsmann[29]3:37,,.,,.Chen[30](PES),(CS),CS/PES,,.3结论与展望,..:1),(PTFE),.2),,.3),,.,,.[1]LeeH,SchererNF,MessersmithPB.Singlemoleculemechanicsofmusseladhesion[J].PNatlAcadSciUSA,2006,103:12999-13003.[2]LeeH,DellatoreSM,MillerWM,etal.Musselinspiredsurfacechemistryformultifunctionalcoatings[J].Science,2007,318:426-430.[3]WaiteJH.Surfacechemistrymusselpower[J].NatMater,2008,7:8-9.[4]SeverMJ,WeisserJT,MonahanJ,etal.Metalmediatedcrosslinkinginthegenerationofamarinemusseladhesive[J].AngewChemIntEdit,2004,43:448-450.[5]YuME,HwangJY,DemingTJ.RoleofL3,4dihydroxyphenylalanineinmusseladhesiveproteins[J].JAmChemSoc,1999,121:5825-5826.[6]ZhaoH,WaiteJH.Linkingadhesiveandstructuralproteinsintheattachmentplaqueofmytiluscalifornianus[J].JBiolChem,2006,281:26150-26158.[7]BurzioLA,WaiteJH.Crosslinkinginadhesivequinoproteins:studieswithmodeldecapeptides[J].BiochemistryUS,2000,39:11147-11153.[8]vanderLeedenMC.Areconformationalchanges,inducedbyosmoticpressurevariations,theunderlyingmechanismofcontrollingtheadhesiveactivityofmusseladhesiveproteins[J].Langmuir,2005,21:11373-11379.[9]XiZY,XuYY,ZhuLP,etal.AfacilemethodofsurfacemodificationforhydrophobicpolymermembranesbasedontheadhesivebehaviorofpolyDOPAandpolydopamine[J].JMembrSci,2009,327:244-253.[10]KuSH,RyuJ,HongSK,etal.Generalfunctionalizationrouteforcelladhesiononnonwettingsurfaces[J].Biomaterials,2010,31:2535-2541.[11]YuF,ChenSG,ChenY,etal.Experimentalandtheoreticalanalysisofpolymerizationreactionprocessonthepolydopaminemembranesanditscorrosionprotectionpropertiesfor304StainlessSteel[J].JMolStruct,2010,982:152-161.[12]LiB,LiuWP,JiangZY,etal.Ultrathinandstableactivelayerofdensecompositemembraneenabledbypolydopamine[J].Langmuir,2009,25:7368-7374.[13]PanFS,JiaHP,QiaoSZ,etal.Bioinspiredfabricationofhighperformancecompositemembraneswithultrathindefectfreeskinlayer[J].JMembrSci,2009,341:279-285.[14]KangSM,YouI,ChoWK,etal.Onestepmodificationofsuperhydrophobicsurfacesbyamusselinspiredpolymercoating[J].AngewChemIntEd,2010,49:9401-9404.[15]YuB,LiuJX,LiuSJ,etal.Pdoplayerexhibitingzwitterionicity:asimpleelectrochemicalinterfaceforgoverningionpermeability[J].ChemCommun,2010,46:5900-5902.[16],,.PTFE[J].,2010,4:479-483.[17]LeeH,RhoJ,MessersmithPB.Facileconjugationofbiomoleculesontosurfacesviamusseladhesiveproteininspiredcoatings[J].AdvMater,2009,21:431-434.383031[18]McCloskeyBD,ParkHB,JuH,etal.Influenceofpolydopaminedepositionconditionsonpurewaterfluxandfoulantadhesionresistanceofreverseosmosis,ultrafiltrationandmicrofiltrationmembranes[J].Polymer,2010,51:3472-3485.[19]JiangJH,ZhuLP,LiXL,etal.SurfacemodificationofPEporousmembranesbasedonthestrongadhesionofpolydopamineandcovalentimmobilizationofheparin[J].JMembrSci,2010,364:194-202.[20]LiCY,WangWC,XuFJ,etal.PreparationofpHsensitivemembranesviadopamine-initiatedatomtransferradicalpolymerization[J].JMembrSci,2011,367:7-13.[21]LiaoY,CaoB,WangWC,etal.Afacilemethodforpreparinghighlyconductiveandreflectivesurface-silveredpolyimidefilms[J].ApplSurfSci,2009,255:8207-8212.[22]LiaoY,WangYQ,FengXX,etal.A