成人斯蒂尔病诊断与治疗

(19582),,,,,,(,510080)(AOSD),,AOSDAOSD;;R59312A167226170(2007)0320015202Diagnosisandtreatmentofadult2onsetStillpsdiseaseYANGXiu2yan(DepartmentofRheumatology,FirstAffiliatedHospital,SunYat2SenUniversity,Guangzhou510080,China)AbstractAdult2onsetStilldisease(AOSD)isaautoimmunerheumatism1ClinicalfeaturesofAOSDarefever,arthral2gia,skinrashandWBCelevation1Laboratoryexaminationsdisplayanonspecificinflammationreaction1Combiningtherapybynon2steroidalanti2inflammatorydrugs(NSAID)andhormonetotreatAOSDhasachievedgoodresults1Thisarticleaimstointro2ducediagnosisandtreatmentofAOSD1KeywordsAdult2onsetStillpsdisease;Diagnosis;Treatment,,[1],,(adultonsetStillpsdisease,AOSD),1AOSDAOSD,;;,AOSD1,39,,,,,,AOSD,AOSD,,,(),()AOSD,,,AOSD35,[2],750g/L,AOSD67139%;1259g/L,AOSD74129%;2500g/L,AOSD83133%[3],,20%,AOSD7015%8312%;5,20%,AOSD4312%9219%[4]2AOSD,AOSD,,88%,AOSD,,,,,A,,,,,512007543,,,AOSD,AOSD,,AOSD[5]:50mg(100mg),121;10mg,1;40ml+15mg(10mg),,1,;;,,,,AOSD,AOSD,AOSD,,,AOSD,AOSD,,,,2(INF2),AOSD[6],INF2/AOSD,[7]AOSD,,,AOSD,[1]1[J]1,2002,33(1):532541[2]Schwarz2EywillM,HeiligB,BauerH,etal1EvaluationofserumferritinasamarkerforadultStillpsdiseaseactivity[J]1AnnRheumDis,1992,51(5):68326851[3],,,1[J]1,2005,9(2):33823411[4]FautrelB,Le2MoelG,Saint2MarcouxB,etal1DiagnosticvalueofferritinandglycosylatedferritininadultonsetStillpsdisease[J]1JRheumatol,2001,28(2):32223291[5],,,1[J]1,2002,2(4):21322161[6]StamTC,SwaakAJ,KruitWH,etal1Regulationofferritin:aspecificroleforinterferon2alpha(IFN2alpha).Theacutephaseresponseinpa2tientstreatedwithIFN2alpha22b[J]1EurJClinInvest,2002,32(1):792831[7]CavagnaL,CaporaliR,EpisO,etal1InfliximabinthetreatmentofadultStillpsdiseaserefractorytoconventionaltherapy[J]1ClinExpRheumatol,2001,19(3):32923321(:2007202209)(19632),,,,,,(,610072)(systemiclupuserythematosus,SLE),SLE,,,;R593124+1A167226170(2007)0320016203IndividualizedtherapyforsystemiclupuserythematosusZHUJing,ZHOUBin(DepartmentofRheumatologyandImmunology,SichuanProvincialPeoplepsHospital,Chengdu610072,China)AbstractSystemiclupuserythematosus(SLE)isadiseaseofhighheterogeneity1ThisarticleemphaticallyelucidatestheindividualizedtreatmentofSLEonthebasisoftheevaluationoftheimpairedorganandseverity,aswellaspatientspphysicalconditionandtolerance1KeywordsSystemiclupuserythematosus;Individualizedtherapy(systemiclupuserythematosus,SLE)612007543