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14120012JournalofIsotopesVol.14No.1Feb.2001:Endostatin1,2(11,610041;21,610030):Endostatin(),,,Endostatin,,,Endostatin:Endostatin();;;:R81715;R962:A:100027512(2001)01250204,[1][2],Endostatin(),,,(12mm),[3,4]Endostatin,[5],,Endostatin,1Endostatin1994O’Reilly[6]LewisAngiostatin(,38kD)1997O’Reilly[7]EOMA,,,Angio2statin,SeohroseS200C4HPLC,,10L500mg2Lg,5000,2%20kD100600LgöL:2000207205;:2000210223:(1966),(),,,,,ÒÐC,20kD,Endostatin,ÒÐEndostatin(22kD)()C(38kD)Endostatin,C22kDEndostatin,120300LgöL,Endostatin,Endostatin,Endostatin,ÒÐEndostatinEndostatinÒÐ,,EndostatinEndostatin,Endo2statinEndostatin,Endostatin,Endostatin2Endostatin,,,,,,,,[3,4]012013mm,,[1],Endostatin,OReillyEndostatinEndostatin[7]Endostatin,NIH3T3A10[8]013mgökgd-1Endostatin,Lewis[7]Endostatin100200mm3LewisT241EomaB16F10,,7Endostatin[7]Dhanabal[9],EndostatinEndostatin,10mgökg,Endo2statinEndostatinBoehm[4]EndostatinLewis,,,;Endostatin,,6,Endostatin,5Blezinger[10],Endostatin3,65%240LgEndo2statin,3,Endostatin3mgöL,7d8mgöL,14d4mgöL(Renca)C47BLCLCBallböc13151::Endostatin,40%,(P0105)6,32%Endostatin,,EndostatinbFGF[11]3EndostatinEndostatin,,,Endostatin,,Endostatin,Endostatin,,,,,,EndostatinEndo2statin18420kD,,,,Endostatin,131I,:B-,99TcmSPECT,186Re188Re[12],188Re186W2188Re,186Re[13]186,188ReB-90Y,C,99Tcm186,188ReEndostatin,EndostatinSH,ReTcÏB,,,99Tcm186,188Re,(MAG3)99Tcm186,188Re[14],MAG3EndostatinMAG32Endostatin,MAG399Tcm186,188Re,,99Tcm2MAG32Endostatin186,188Re2MAG32Endostatin,:[1]FolkmanJ.WhatIstheEvidenceThatTumorsAreAngiogenesisDepartment[J].JNatlCancerInst,1989,82(1):4.[2]1[J]1[],2000,27(1):141[3]KerbelRS.ACancerTherapyResistanttoResistance[J].Nature,1997,390(6658):3351[4]BoehmT,FolkmanJ,BrowderT,etal.AntiangiogenicTherapyofExperimentalCancerDoseNotIn2duceAcquiredDrugResistance[J].Nature,1997,390(6658):404.2514[5],1[J]1,1999,6(1):611[6]O’ReillyMS,HolmtrenL,ShingY,etal.Angiostatin:ANovelAngiogenesisInhibitorThatMediatestheSuppressionofMetastasesbyaLesisLungCarcinoma[J].Cell,1994,79(2):3151[7]O’ReillyMS,BoehmT,ShingY,etal.Endostatin:AnEndogenousInhibitorofAngiogenesisandTu2morGrowth[J].Cell,1977,88(2):277.[8]DhanabalM,VolkR,RamchandranR,etal.Cloning,Expression,andinVitroActivityofHumanEndostatin[J].BiochemNiophysResCommun,1999,258(2):345.[9]DhanabalM,RamchandranR,VolkR,etal.Endostatin:YeastProduction,Mutants,andAntitumorEffectinRenalCellCarcinoma[J].CancerRes,1999,59(1):189.[10]BlezingerP,WangJ,GondoM,etal.SystemicInhibitionofTumorGrowthandYumorMetastasesbyIntramuscularAdministrationoftheEndostatinGene[J].NatBiotechnol,1999,17(4):343.[11],1Endostatin[J]1,2000,7(1):761[12]WesselsB,RogusRD.RadionuclideSelectionandModelAbsorbedDoesCalculationsforRadiolabeledRumor2associatedAntibodies[J].MedPhy,1984,11(4):638.[13]GriffithsGL,GoldenbergDM,KnappJrFF,etal.DirectRadiolabelingofMonoclonalAntibodiesWithFeneratorProducedRhenium2188forRadioimmunotherapy:LabellingandAnimalBiodistribu2tionStudies[J].CancerRes,1991,51(12):4594.[14],,1186,188Re2MAG32McAb[J]1,1997,4(2):1401ANovelandPotentialRadionuclideCarrierforDiagnosingandTherapyingTumor:EndostatinLIYun2chun1,XIAORong2gui2(1.DepartmentofNuclearMedicineofFirstUniversityHospital,WestChinaMedicineCenter,SichuanUniversity,Chengdu610041,China;2.TheResearchInstituteofMedicalInformationofSichuan,Chengdu610041,China)Abstract:Endostatincaninhibitthegrowth,proliferation,metastasisoftumor,andnotleadtumortoproducemedicine2resistance.Afterlabeledwithradionuclide,thelabeledendo2statincanbeusedinphotography,biologicalandradiotargetingtherapyoftumor.So,ithassignificantvaluetostudyendostatinlabeledwithradionuclide.Keywords:Endostatin;Yumor;Radionuclide;Carrier351::Endostatin