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Simultaneousdeterminationofthirtynon-steroidalanti-inflammatorydrugresiduesinswinemusclebyultra-high-performanceliquidchromatographywithtandemmassspectrometryxxxx大学xxx201x.xx.xx11.Simultaneouslyanalyze30NSAIDs2.Complexmatrix:swinemuscle3.Newdetectionmethod:UHPLC/MC/MCMajorAdvantages:2SamplePreparation:5gswinemuscle15mLacidicacetonitrile2ganhydroussodiumsulfate15mLn-hexanesaturatedwithacetonitrileN2,5mLmethanol–phosphoricacidHLBcartridge4mLammoniumhydroxide–acetonitrile–methyltert-butylether4mLmethyltert-butyletherN2,1mLacetonitrile–0.1%formicacidmembranefilterUHPLC/MC/MC3Optimizationofextractionprocedure:4MethodValidation:1.LOD:0.4-2.0μg/kg2.LOQ:1.0-5.0μg/kg3.Recoveries：61.7%-125.7%4.Precision:repeatability8%5.Linearity:r＞0.99005RealsampleanalysisDetectionketoprofenacetaminophensalicylicacidaminoantipyrine6Conclusions1.ThisstudyappliedUHPLC–MS/MStoestablishamethodforsimultaneousdeterminationofmulti-residueofthirtynon-steroidalanti-inflammatorydrugsinswinemuscle.2.Extractionandpurificationconditionsformulti-residueanalysisinanimaloriginalfoodproductswerein-depthdiscussed.3.Thismethodwasreliable,convenientandsensitive.Moreover,itmettherequirementofresidueanalysisforNSAIDs.7谢谢大家！8