The-pilot-plant-real-book-2nd

AvailableoutsidetheUSfromthefollowingbookdealersN.O1-606,RongleEastRd.,SongjiangShanghai,ChinaPostcode:201613Attn:JohnQianTEL:0086-2137745175FAX:[phone]EMAIL:[e-mail]:18701898909中试书中国中代理ThePilotPlantRealBook,byFrancisX.McConville,isauniqueandhighlypracticalnewhandbookforR&Dchemists,chemicalengineers,technicians,andstudents.Bridgingthegapbetweenchemistryandengineering,itisdesignedforprocessR&D,kilo-labandpilotplantpersonnel,andispackedwithinformationforthesafeandeffectivescale-upofnewprocesses.Therevisedandexpanded2ndeditionisrichlyillustratedwithover200distinctivecharts,graphs,figuresanddatatables,andcontainscountlesstipsandtechniques,anexhaustiveindex,bibliographyandrecommendedreadinglist.320pages,8.5x11inches,two-color,robustlay-flatbinding.FrancisX.McConvillehasover35yearsofexperienceinthechemicalandrelatedindustries,includingprocessdevelopmentandscale-up,withexpertiseinasymmetriccrystallization,biocatalyticconversionandfermentationaswellastraditionalchemicalsyntheticmethods.HeisperhapsbestknownastheauthorofthePilotPlantRealBook,auniquehandbookforprocessdevelopmentpersonnel,whichhewroteandself-publishedin2006.Mr.McConvillespent14yearsasaprocessengineeratSepracor,Inc.wherehehelpeddevelopcost-effectiveprocessesfornumerouspharmaceuticalactivesandintermediates.Hewasakeymemberofthetechnologytransferandscale-upteamsforthecompany'scollaborationsinAsia,EuropeandNorthAmerica.HewaseducatedatWorcesterPolytechnicInstitute,fromwhichheholdsMastersdegreesinbothBiotechnologyandChemicalEngineering,aswellasaBachelor'sdegreeinChemistry.Thisvariedbackgroundallowshimtobringauniqueandvaluablemixofskillstohiswork.HenowworksasaconsultantandtraininginstructorandliveswithhisfamilyinWorcester,Massachusetts.Seehiscompletecurriculumvitae.Abriefdescriptionofthecontents:•Propertiesofcommonsolvents,gases,reagents,buffers,andheattransferfluids...azeotropes,boilingpointrelationships,flammability,pKa,solubilityandchemicalcompatibilitytables...conversionsandmathematicalformulae...•Clear,concisemonographsonheattransfer,temperaturecontrol,agitation,distillation,extraction,crystallization,filtrationanddrying...reactors,TCU's,chillers,motors,pumps,electricity,intrinsicsafetyandprocesscontrol...•Safepracticesforhandlingofflammablesolvents,compressedgases,toxicsubstancesandelectricalequipment...hazardousmaterialsclassifications,selectionofpersonalprotectiveequipment...•Theroleofthepilotplantinchemicaldevelopment,guidelinesfordevelopingscalablereactions,processsafetyscreening,Haz-Ops,cGMP,tipsformaximizingefficiencyandgettingthemostoutofprocessscale-up...andmuchmore...TABLEOFCONTENTSChapter1-ThePilotPlantTheRoleofthePilotPlant1-2MajorFactorsinScale-Up1-312ThingstoDoDuringProcessScale-Up1-612ThingstoAvoidDuringProcessScale-Up1-7DevelopingScalableReactions1-8TheRoleofCalorimetryandProcessSafetyScreening1-11TheHaz-Op1-12TheBatchChecklist1-14TheProcessFlowDiagram1-15TheBatchRecord1-16TheCampaignReport1-17NotesonGMP1-18Chapter2-EquipmentandOperationsThePilotPlantEquipmentTrain2-2NotesonEquipmentSelection,InstallationandMaintenance2-3Reactors2-4VesselAgitation2-8ChargingRawMaterials2-11ReactionControl2-13SamplingforReactionMonitoring2-15Workup2-16PartitionCoefficientandExtractionEfficiency2-17PolishFiltration/Decolorization/WaterRemoval2-18BatchDistillation2-19Crystallization2-21ProductIsolation2-24FiltrationScale-Up2-27ProductDrying2-29Scrubbers2-33ReactorandEquipmentCleaning2-34Chapter3-LiquidHandlingIntroductionandTerminology3-2PumpSizingandSelection3-4PumpInstallationandOperation3-5RotaryPumpTroubleshootingGuide3-6MajorPumpTypes3-7DiaphragmPumpTroubleshootingGuide3-8PeristalticPumpTubingSizingandFlowrateGuides3-13Pipe,DrawnTubeandFittings3-14FlangesandGaskets3-19Valves3-21HoseandHoseFittings3-23LiquidVelocityandPressureEffects3-24ViscosityEffects3-26StandardO-RingSizeChart3-28RubberStopperSizes3-29GroundGlassJointSizes3-29CapacityofLiquidStorageTanks3-30StorageDrumandShuttleData3-32Chapter4-HeatTransferHeatTransferinStirredTankReactors4-2TypicalBatchCoolingProfiles4-4ReactorHeatTransferCoefficients4-5ExperimentalDeterminationofHeatTransferCoefficient4-7HeatExchangerFundamentals4-8ExampleHeatExchangerProblem4-9ChartforEstimatingLogMeanTemperatureDifference4-10TemperatureControlUnits4-11SystemStart-upandOperation4-12TipsonUsingHeatTransferFluidsinTCUs4-13HeatTransferFluidSelection4-14SpecificHeatofVariousHeatTransferFluidsvs.Temperature4-15UsefulTemperatureRangesandPropertiesofCommercialHTF抯4-16NotesontheUseofGlycolHTFs4-18SpecificGravityofAqueousGlycolSolutions4-19FreezingPointsofAqueousGlycolSolutions4-20BoilingPointsofAqueousGlycolSolutions4-21SpecificHeatsofAqueousGlycolSolutions4-22ViscosityofAqueousEthyleneGlycolSolutions4-23FreezingPointsofBrines4-24SteamPressurevs.Temperature4-25NotesonProcessChillers4-26ApproximateChillerCapacity4-28EffectofCondenserCoolingWaterTemperature4-28Chapter5-ElectricityandIstrumentationNotesonElectricalSafety5-2ElectricPowerBasics5-3WireData5-4StandardResistorColorCode5-5TipsonMakingElectricalC