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28620076ChineseJournalofScientificInstrumentVol128No16Jun.2007:2005211ReceivedDate:20052113:(20205006)(2004BA210A04)31,1,1,1,1,1,1,2(1130021;2130051):,,()Paul,,(500),,,,:;;;:O657.6:A:150.253NewprogressesinthedevelopmentofminiatureiontrapmassspectrometersLiMing1,FeiQiang1,ChenHuanwen1,JinWei1,JiangJie1,JinQinhan1,ZhouJianguang1,XuXiaoyu2(1DepartmentofChemistry,JilinUniversity,JilinProvinceResearchCenterforEngineeringandTechnologyofSpectralInstruments,JilinUniversity,Changchun130021,China;2InstituteofForensicScience,PublicSecurityDepartmentofJilinProvince,Chuangchun130051,China)Abstract:Tomeettherequirementofscienceandtechnologydevelopment,theminiaturizationofmassspectrometerhasbecomeoneoftheimportanttrendsinanalyticalinstrumentdevelopment.Miniaturizediontrapmassspectrome2terhasgainedgreatachievements.Theminiaturizationoftheiontrapwasachievedbyusingsmallerpumps,asmal2lervacuumsystemandlowerRFvoltage,aswellasasimplifiedtrapgeometry(fromhyperbolictocylindrical,thentorectilinear).LikeotherformsofPauliontraps,thecylindricaliontrapalsosuffersfromthedrawbacksoflowtrappingefficiencyforexternalioninjectionandlowtrappingcapacity(500ionsforcommercialsizeiontrap),especiallywhenthetrapsizeisdecreasedforoperationatlowerRFvoltage.Inordertoovercomethesedisadvanta2ges,anewiontrapmassanalyzerwitharectilineargeometryhasbeeninvented.Themechanismofminiaturizationofiontrapmassanalyzerisintroducedandthenewprogressesinthedevelopmentofminiatureiontrapmassspectrome2tersarereviewedinthispaper.Keywords:iontrap;miniature;massspectrometer;review1,,,1kg2L5W,114828[1],,,[223][425](TOF)[627](FT2ICR)[829],FT2ICRTOF,:[10];;,,;,/,[11212]22050,Paul[13](quadrupolemassfilter),,3,2(end2cap)1(ringelectrode),11PaulFig.1PauliontrapMathieu,Mathieu:d2ud2+(au-2qucos2)u=0:ux,y,z;,t/2,,t;auqu,(trappingparameters)Mathieu:az=-eUDCmr022,qz=-4eVRFmr022:az;qzUDC;VRF;r0:,7000V,,,,,,,,(10-1Torr),,,,(MS/MSMSn),,,,:azqz,azqz,2[14]2Fig.2Stabilitydiagramoftheiontrap2,2qz,,V,qzqz=0.908,,,V,,0,qz0.908V,qz=0.707,qz6:1149,,(0,0.707),,m/z,,MSn3(),3[15]3Fig.3Conceptualevolutionoftherectilineariontrapanditsrelationshipwithotheriontraps3.1[16],1/21/4(0.5cm0.25cm),,,70000Da,3.2,Cooks[17](CIT),,,,r=1.0cmz=0.897cm,,,600Th,,CIT,Cooks[18],2.5mm,,CIT2.5mm,300170V,146,100,,500ppb[18];Ramsey[19]0.5mm1.0mm2.0mm,,;0.5mm0.25ThRamsey[20],Xe0.2Th[10]15kg,,150W,,,Cooks[21]2.5mm,,1.24ppbCIT,qz,,Cooks[22]CIT,(RF/DC),(SWIFT),CITm/z,CIT[23224][3,25]CITCIT,,CIT,r02.5mmCIT4CIT2CIT(4CIT2),Cooks[26]CIT,,2.5mm,50500Th,0.3Th3.3,(3D),:,CIT(5%),,,Cooks[15,27228](rectilineariontrap,RIT),41150284Fig.4Thestructureoftherectilineariontrap(lin2eariontraP2LIT)[29],,LIT(4),XY,XY,Z()(10-3Torr),,,;,,XYMathieu4mm4mm,40[15],,,,(PFTBA),;650Th;,m/z502,1200Cooks[30],,0.999999,146,0.3ThMini10[31]10kg,70W,,500,50ppb,,,,4,[1]BADMANER,COOKSRG.Miniaturemassanalyzers[J].J.MassSpectrom.,2000,35:6572671.[2]HOLKEBOERDH,KARANDYTL,CURRIERFC,etal.MiniaturequadrupoleresidualgasanalyzerforprocessmonitoringatmilliTorrpressures[J].J.Vac.Sci.Tech2nol.A,1998,16:115721162.[3]FERRANRJ,BOUMSELLEKS.High2pressureeffectsinminiaturearraysofquadrupoleanalyzersforresidualgasanalysisfrom10$9to10$2Torr[J].J.Vac.Sci.Technol.A,1996,14:125821265.[4]SINHAMP,GUTNIKOVG.Developmentofaminiatur2izedgaschromatographmassspectrometerwithamicro2borecapillarycolumnandanarraydetector[J].Anal.Chem.,1991,63:201222016.[5]BURGOYNETW,HIEFTJEGM,HITESRA.Designandperformanceofaplasma2sourcemassspectrograph[J].J.Am.Soc.MassSpectrom.,1997,8:3072318.[6]WHITEAJ,BLAMIREMG,MULLOCKSJ.Develop2mentofaportabletime2of2flightmembraneinletmassspectrometerforenvironmentalanalysis[J].Rev.Sci.Instrum.,1998,69:5652571.[7]MATSUOT,ISHIHARAM,ROSENBAUERH.Aspacetime2of2flightmassspectrometerforexobiologically2orien2tedapplications[J].Adv.SpaceRes.,1999,23:3412348.[8]PRIETOMC,DIETRICHD,KEVILLER,etal.Pro2ceedingsofthe45thASMSConferenceonMassSpectrom2etryandAlliedTopics[C].PalmSprings:CA,June151997.[9]MILLERG,KOCHM,HSUJP,etal.Proceedingsofthe45thASMSConferenceonMassSpectrometryandAl2liedTopics[C].PalmSprings:CA,June151997.[10]RITERLS,PENGY,COOKSRG.Analyticalperform2anceofaminiaturecylindricaliontrapmassspectrometer[J].Anal.Chem.,2002,74:615426162.[11]RITERLS,COOKSRG.Ion/moleculereactionsper2formedinaminiaturecylindricaliontrapmassspectrom2eter[J].Analyst,2003,128(9):111221118.[12]CHENHW,XUR,COOKSRG.Ion/moleculereac2tionsinaminiatureRITmassspectrometer[J].JournalofMassSpectrometry.inpress.[13]PAULW,STEINWEDELH.Verfahrenzurtrennungbzw.zumgetrenntennachweisvonionenverschiedenerspezifischerladung:German,944900[P].1956.6:1151[14]DAWSONPH.Quadrupolemassspectrometryanditsapplication[M].Amsterdam:ElsevierScientificPub2lishingCompany,1976.[15]OUYANGZ,WUG,COOKSRG.Rectilineariontrap:concepts,calculations,andanalyticalperformanceofanewmassanalyzer[J].Anal.Chem.,2004,76(16):459524605[16]KAISERRE,COOKSRG.,STAFFORDGC,etal.Operationofaquadrupoleiontrapmassspectrometertoachievehighmass/chargeratios[J].Int.J.MassSpec2trom.IonProcesses,1991,106:792115.[17]WELLSJM,ETHANRB,COOKSRG.Aquadrupoleiontrapwithcylind