医学PPT课件糖皮质激素在血液病中的应用

ThispapermainlyintroducesthedesignofanintelligenttemperaturecontrolsystemwhichrealizesthefunctionoftemperaturemeasurementandcontrolbyusingsinglebusdigitaltemperaturesensorDS18B20andsinglechipmicrocomputer.ThecorecomponentsofthesystemareAT89C51microcontrollerandDS18B20temperaturesensor.糖皮质激素在血液病中的应用中山大学附属第三医院血液科李旭东主治医师ThispapermainlyintroducesthedesignofanintelligenttemperaturecontrolsystemwhichrealizesthefunctionoftemperaturemeasurementandcontrolbyusingsinglebusdigitaltemperaturesensorDS18B20andsinglechipmicrocomputer.ThecorecomponentsofthesystemareAT89C51microcontrollerandDS18B20temperaturesensor.概述肾上腺皮质所分泌激素–盐皮质激素–糖皮质激素–性激素ThispapermainlyintroducesthedesignofanintelligenttemperaturecontrolsystemwhichrealizesthefunctionoftemperaturemeasurementandcontrolbyusingsinglebusdigitaltemperaturesensorDS18B20andsinglechipmicrocomputer.ThecorecomponentsofthesystemareAT89C51microcontrollerandDS18B20temperaturesensor.糖皮质激素效能的比较药名半衰期(分)水盐代谢作用糖代谢作用抗炎作用作用持续时间等效剂量(mg)中效强的松(Predinsine)2000.63.53-412-36hr5中效甲基强的松龙(Nethypredison)2000.555.012-36hr4长效地塞米松(Dexamethason)300接近0303036-54hr0.75ThispapermainlyintroducesthedesignofanintelligenttemperaturecontrolsystemwhichrealizesthefunctionoftemperaturemeasurementandcontrolbyusingsinglebusdigitaltemperaturesensorDS18B20andsinglechipmicrocomputer.ThecorecomponentsofthesystemareAT89C51microcontrollerandDS18B20temperaturesensor.皮质激素的生理和药理作用对代谢的影响抗炎作用免疫抑制作用抗毒作用抗休克作用对中枢神经系统的作用对血液和造血系统的影响ThispapermainlyintroducesthedesignofanintelligenttemperaturecontrolsystemwhichrealizesthefunctionoftemperaturemeasurementandcontrolbyusingsinglebusdigitaltemperaturesensorDS18B20andsinglechipmicrocomputer.ThecorecomponentsofthesystemareAT89C51microcontrollerandDS18B20temperaturesensor.皮质激素的生理和药理作用1.对代谢影响：(1)抑制组织对葡萄糖的摄取和利用，促进糖元异生(2)蛋白质代谢：使肌肉、皮肤、结缔组织的蛋白质分解增强，负氮平衡(3)脂肪代谢：重新分布(4)水和电解质的影响：保钠排钾，抑制抗利尿激素，利尿作用ThispapermainlyintroducesthedesignofanintelligenttemperaturecontrolsystemwhichrealizesthefunctionoftemperaturemeasurementandcontrolbyusingsinglebusdigitaltemperaturesensorDS18B20andsinglechipmicrocomputer.ThecorecomponentsofthesystemareAT89C51microcontrollerandDS18B20temperaturesensor.皮质激素的生理和药理作用2.抗炎作用：(1)阻止急性炎症所致的毛细血管通透性增加(2)抑制白细胞进入血管内皮渗透毛细血管壁(3)抑制炎症组织释放组胺、5-羟色胺、激肽、前列腺素等介质(4)稳定溶酶体膜(5)抑制纤维母细胞增生，胶原沉积、新毛细血管和疤痕组织形成ThispapermainlyintroducesthedesignofanintelligenttemperaturecontrolsystemwhichrealizesthefunctionoftemperaturemeasurementandcontrolbyusingsinglebusdigitaltemperaturesensorDS18B20andsinglechipmicrocomputer.ThecorecomponentsofthesystemareAT89C51microcontrollerandDS18B20temperaturesensor.皮质激素的生理和药理作用3.免疫抑制作用：(1)抑制单核巨噬细胞的吞噬作用(2)使淋巴细胞溶解，使循环中辅助性T细胞减少(3)降低自身免疫性抗体水平ThispapermainlyintroducesthedesignofanintelligenttemperaturecontrolsystemwhichrealizesthefunctionoftemperaturemeasurementandcontrolbyusingsinglebusdigitaltemperaturesensorDS18B20andsinglechipmicrocomputer.ThecorecomponentsofthesystemareAT89C51microcontrollerandDS18B20temperaturesensor.皮质激素的生理和药理作用4.抗毒作用：(1)提高机体对有害刺激的应激能力，减轻毒血症状；(2)减少内热原释放，降低体温调节中枢对热原的敏感性，对感染的高热有退热作用。ThispapermainlyintroducesthedesignofanintelligenttemperaturecontrolsystemwhichrealizesthefunctionoftemperaturemeasurementandcontrolbyusingsinglebusdigitaltemperaturesensorDS18B20andsinglechipmicrocomputer.ThecorecomponentsofthesystemareAT89C51microcontrollerandDS18B20temperaturesensor.皮质激素的生理和药理作用5.抗休克作用：(1)降低血管对各种活性物质敏感性，解除血管痉挛，使血液动力学恢复正常(2)稳定溶酶体膜，阻止过敏介质释放。ThispapermainlyintroducesthedesignofanintelligenttemperaturecontrolsystemwhichrealizesthefunctionoftemperaturemeasurementandcontrolbyusingsinglebusdigitaltemperaturesensorDS18B20andsinglechipmicrocomputer.ThecorecomponentsofthesystemareAT89C51microcontrollerandDS18B20temperaturesensor.皮质激素的生理和药理作用6.对中枢神经系统的作用：提高中枢神经系统的兴奋性。ThispapermainlyintroducesthedesignofanintelligenttemperaturecontrolsystemwhichrealizesthefunctionoftemperaturemeasurementandcontrolbyusingsinglebusdigitaltemperaturesensorDS18B20andsinglechipmicrocomputer.ThecorecomponentsofthesystemareAT89C51microcontrollerandDS18B20temperaturesensor.皮质激素的生理和药理作用7.对血液和造血系统：使红细胞、血小板生成增多，嗜酸细胞、淋巴细胞减少。ThispapermainlyintroducesthedesignofanintelligenttemperaturecontrolsystemwhichrealizesthefunctionoftemperaturemeasurementandcontrolbyusingsinglebusdigitaltemperaturesensorDS18B20andsinglechipmicrocomputer.ThecorecomponentsofthesystemareAT89C51microcontrollerandDS18B20temperaturesensor.皮质激素的不良反应1.药源性类皮质醇增多症2.肌萎缩和骨质疏松3.诱发加重感染4.诱发加重溃疡5.诱发精神症状6.停药反应：禁突然停药ThispapermainlyintroducesthedesignofanintelligenttemperaturecontrolsystemwhichrealizesthefunctionoftemperaturemeasurementandcontrolbyusingsinglebusdigitaltemperaturesensorDS18B20andsinglechipmicrocomputer.ThecorecomponentsofthesystemareAT89C51microcontrollerandDS18B20temperaturesensor.血液病中的适应证免疫性疾病：AIHA、ITP、再生障碍性贫血、纯红再障恶性血液病：急性白血病、慢性白血病、淋巴瘤、MM其他：G-6PD缺乏症、PNH、TTP、特发性嗜酸细胞增多症ThispapermainlyintroducesthedesignofanintelligenttemperaturecontrolsystemwhichrealizesthefunctionoftemperaturemeasurementandcontrolbyusingsinglebusdigitaltemperaturesensorDS18B20andsinglechipmicrocomputer.ThecorecomponentsofthesystemareAT89C51microcontrollerandDS18B