聚氨基酸共聚物合成研究进展

224Vol.22,No.420067POLYMERMATERIALSSCIENCEANDENGINEERINGJul.2006X张国林1,吴秋华1,宋溪明1,魏天柱1,赵丽萍1,2,关　玲1(1.,110036;2.,111003):聚氨基酸共聚物是一类新型生物降解高分子材料。文中简单综述了聚氨基酸-聚醚嵌段共聚物、聚氨基酸-甲壳素共聚物、聚氨基酸-硅氧烷共聚物和聚氨基酸-聚酯共聚物的合成方法。:;;:TB39:A:1000-7555(2006)04-0010-05,,,,[1],[2,3]Hoste[4]Giammona[5],,,,[6],,,,,,,1-(PEG),PEG,,,[79]PEG,[10,11],(FDA),PEG,,PEG,,-,(PEG),(PEG-NH2),PEG-NH2(Scheme1A)Kang[12](PEG),-,Kataoka[13]Bogdanov[14]-,,Lee[15]Cammas[16]X:2005-12-28;:2006-04-07:(20051023):,,E-mail:[e-mail]-,Takao[17]-,,--,[1821]Scheme1Scheme2Scheme3(PEG)(MPEG),,MPEG-NH2,-NCA-[22,23](Scheme1B),,Cho[24][-](BPEOBA),C---NCA,--(Scheme2),2-()(),,,,,Aiba[25],Kurita[26]--(Scheme3),114:3-Wang[27]--(Scheme4),,pHScheme4Scheme5Scheme6Scheme7Scheme5NCA5,1,CO22,2NCA4---,(FDA),Donise[28]-,(Scheme6)Helder[29,30]E-,-,,,-[31](Scheme7)Ouchi[32],,-,(Scheme8)122006Scheme85,:[1]RypacekF.PolymerDegradationandStability,1998,59:345351.[2]GonsalvesKE,MungaraPM.TrendsPolym.Sci.,1996,4:2530.[3]OppermannFB,PickartzS.PolymerDegradationandStability,1998,59:337342.[4]HosteK,SchachtE,SeymourL.JournalofControlledRelease,2000,64:5361.[5]GiammonaG,PitarresiG,TomarchioV,etal.JournalofControlledRelease,1998,51:249257.[6]BlontER,KarisonRH.J.Am.Chem.Soc.,1956,78:941947.[7]HeroldDA,KeilK,BrunsDF.BiochemPharmacol,1989,38:7378.[8]KazuteruM,NobuhikoY.JournalofControlledRelease,1997,45:209214.[9]YamaokaT,TabataY,IkadaY.J.Pharm.Sci.,1994,83:601606.[10]ZalipskyS.Adv.Drug.DeliveryRev.,1995,16:157182.[11]GreenwaldRB,PendriA,BolikalD.J.Org.Chem.,1995,60:331336.[12]KangIK,TtoY,SisidoM.PolymerJournal,1987,19:13291339.[13]KataokaK,IshiharaA,HaradaA,etal.Macro-molecules,1998,31:60716076.[14]BogdanovAA,MartinJC,BogdanovaAV.Bioconju-gateChem.,1996,7:144149.[15]WonCY,ChuCC,LeeJD.JournalofPolymerSci-ence:PartA:PolymerChemistry,1998,36:29492959.[16]CammasS,HaradaA,NagasakiY,etal.Macro-molecules,1996,29:32273231.[17]TakaoAY,SugiKI,SakuraiY.ColloidsandSurfacesB:Biointerfaces,1999,16:237242.[18]YuL,GlenS,KwonG.PhramaceuticalResearch,2000,17:59.[19]YuBG,OkanoK,KataokaK,etal.JournalofCon-trolledRelease,1998,53:131136.[20]KataokaK,MatsumotoT,YokoyamaM,etal.Ornal.ofControlledRelease,2000,64:143153.[21]YokoyamaM,SatohA,SakuraiY,etal.JournalofcontrolledRelease,1998,55:219229.[22]ZhangGL,MaJB,LiYH,etal.J.Biomater.Sci.:Polym.Edn.,2003,14:13891400.[23](ZHANGGuo-lin),(MAJian-biao),(WANGYi-nong).(Chem-icalJournalofChineseUniversities),2006,27(4):767770.[24]ChoCS,JeongYI,KimSH,etal.Polymer,2000,41:51855193.[25]AibaS,MinouraN,FujiwaraY.Int.J.Biol.Macro-134:mol.,1985,7:120124.[26]KuritaK,YoshidaA,KoyamaY.Macromolecules,1988,21:15791583.[27]WangYL,ChangYC.Macromolecules,2003,36:65036510.[28]DoniseA.Macromolecules,1995,28:425431.[29]HelderJ,FeijenJ.Makromol.Chem.Rapid.Com-mun.,1986:193198.[30]IntVeldPJA,DijstraPJ,FeijenJ.Makromol.Chem.,1992,193:27132716.[31]GoodmanM,GilonC.IsraelJournalofChemistry,1972,10:867871.[32]OuchiT,MiyazakiH,ArimuraH.JournalofPolymerScience:PartA:PolymerChemistry,2002,40:12181225.AdvanceintheSynthesisofPoly(AminoAcid)CopolymersZHANGGuo-lin1,WUQiu-hua1,SONGXi-ming1,WEITian-zhu1,ZHAOLi-ping1,2,GUANLing1(1.InstituteofChemicalScienceandEngineering,LiaoningUniversity,Shenyang110036,China;2.CollegeofPetrochemacalEngineering,ShenyangUniversityofTechnology,Liaoyang111003,China)ABSTRACT:Poly(aminoacid)copolymersareconsideredtobepromisingbiomedicalmaterials,haveapotentialforbiodegradablemedicalapplicationssuchastemporaryartificialskinsubstrates,polymercarriersforproteinconjugatesanddrugdeliverysystems.Inthispaper,thesynthesismethodsaboutthecopolymersofpoly(aminoacid)-polyester,poly(aminoacid)-chitosan,poly(aminoacid)-siloxaneandpoly(aminoacid)-polyesterwereintroduced.Keywords:poly(aminoacid)copolymers;biodegradablematerial;synthesis(9continuedfromp.9)AdvancesinHydrophilizationofPolypropyleneMicroporousMembraneYANGJian1,2,WANGXiao-lin1(1.DepartmentofChemicalEngineering,TsinghuaUniversity,Beijing100084,China;2.TianjinInstituteofMedicalEquipment,Tianjin300161,China)ABSTRACT:Themicroporousmembranefabricatedbypolypropylenehascharactersofgoodmechani-calpropertyandchemicalstabilitytobeusedascellseparatorandbasematerialofbipolarmembrane.Thepolypropylenemembraneafterhydrophilictreatmentrepresentsgoodprospectofapplicationsintheindustryofwatertreatment.Thefabricationmethods:thermallyinducedphaseseparationmethodandmelt-extrudedandcold-stretchingmethodwererecommendedinthisreview.Abouthydrophilicmodificationofpolypropylenemembrane,thecharactersandtechnologiesofhydrophilicmethods,suchasinitiatorinducing,ozonetreatment,radiation(ultraviolet,electronbeam,ionbeamandC-ray)treatment,lowtemperatureplasmatreatmentandblending,werediscussedindetails.Finally,themorphologiesandapplicationsofhydrophilicpolypropylenemembranewerealsointroducedbriefly.Keywords:polypropylene;microporousmembrane;hydrophilization142006