细胞凋亡通路精美示意图

细胞生物学教学课件制作必备——细胞凋亡通路精美示意图TNFReceptorFamilyCysteine-richdomainTNFR1433aaFAS335aaTRAIL-R1(DR4)468aaTNFR2439aaTRAIL-R2(DR5)385aaTRAMP(APO3,LARD)392aaLNGFR427aaTRAIL-R3(DcR1)259aaTRAIL-R4(DcR2)386aaCRDCRDCRDCRDTNFRdomainDDDeathdomainDDCRDCRDCRDCRDCRDCRDCRDDDCRDCRDCRDDDCRDCRDDDCRDCRDCRDCRDDDCRDCRDCRDDDCRDCRDCRDCRDCRDCRDCRD(DR6)613aaDDCRDCRDCRDCRDRANK-R595aaCRDCRDCRDOsteopro-tegerin401aaDDCRDCRDCRDCRDILA(4-1BB)238aaCRDCRDCRDTNFDDR1DDR1DDR1TNFR1andFASsignalinginnecrosisDeathDomainsFADDFADDTRADDFAS-LDDDDDDFADDFADDFADDFADDRIPKinaseRIPKinasePhosphorylatedIntermediate(s)ROSNECROSISTNFDDR1DDR1DDR1DDR1DDR1DDR1TNFR1SignalinginapoptosisSODDDeathDomainSODDSODDTNFTNFTNFSODDCas8FADDFADDFADDFADDCas10Casp10FLIPCasp8BidBcl-2CCCCCCCCCCCCCCCasp6Casp7Casp3CCCCEndoGEndoGEndoGEndoGDiabloAIFCaspaseSubstratesAIFDISCRAIDCARDCARDCasp2cIAPDiabloApaf1CARDCCAIFBAP31p20CaspasetargetsinapoptosisCasp10Casp6Casp8Casp7Casp3Apaf1Apaf1Casp9Casp9CARDCCARDCARDCasp2MDM2FodrinPrese-nelin2GelsolinActinLaminADNAfragmentationandchromatincondensationCytoskeletonCellshapeandmembraneblebbingCADTrans-glutaminaseTopo-isomerasePARPDNA-PKEndoGICADKeratin-18Gas2Cellcycleandotherp21FAKhnRNP-cateninNuMASREB1CalpastatinEMAPIIRock-1Roleofp53inapoptosisCasp3Caspase3SubstratesO-,OH-,NO-CApaf1CARDBaxp53p53Apaf1CARDAAAAAAAAAAAAAAAAAAAAPumaNOXABaxATMChK2GenotoxicstressCCS15S20MDM2PARCPin1BidAAAAAAAAAAFASROSinapoptosisCasp3Caspase3SubstratesBaxBaxRYRO-,OH-,NO-BaxBakBaxBakDiabloCCCCCCCCCCCCCCCCCCDiabloDiabloCCCApaf1CARDSMaseCathepsinsCeramideLysosomeBidBaxCathepsinp53BidBcl-2CCCCCCCCCCCCCasp3CCCCEndoGEndoGEndoGDiabloCaspase3SubstratesAIFcIAPDiabloMitochondriaandERinapoptosisDiabloCCCCCCCCCCCCCBaxBakBaxBakAIFDiabloPTPBcl-XLBcl-2BaxBaxBaxIre-1PERK28SeIF2CathepsinCApaf1CARDCCBaxBaxm-CalpainRYRCasp12FAS-LSignalinginapoptosisDDDDDDFAS-LFAS-LDDDDDDFADDFADDFADDFADDCas8FAS-LDDDDDDFADDFADDFADDFADDCas10Casp10Casp6FADDFADDDDDEDFLIPCasp8BidBcl-2CCCCCCCCCCCCCCCasp7Casp3Apaf1Apaf1Casp9Casp9CCCCEndoGEndoGEndoGEndoGDiabloAIFCaspase3SubstratesAIFCARDCCCARDDISCFAS-LFAS-LRAIDCARDRAIDCARDCasp2cIAPDiabloBAP31p20DNAdamage-inducedapoptosisCasp3Caspase3SubstratesCCCCApaf1CARDBidBaxp53Bcl-2p53Apaf1CARDAAAAAAAAAAAAAAAAAAAAPumaNOXABaxIRATMChk2p53CCMDM2S15S20PARCPin1BidAAAAAAAAAAFAS