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PERSONALSTATEMENTIdecidedtopursuethePhDinmedicinalchemistryfortwomajorreasons:firstly,Iamfascinatedwiththeprocessofdrugdiscoveryandsynthesis,andsecondly,IwishtohelpfindawaytointegrateTraditionalChineseMedicine(TCM)withmodernscience.TheexperiencesofrecoveriesfromcommoncoldandhighfeverwhenIwasakidbydrinkingcupsof“medicatedsoup”decoctedfrommorethantenkindsofherbsprescribedbyanoldTCMdoctorwithprofessionalinheritanceofmanygenerationshavemadedeepandlonglastingimpressiononme.TCMischaracterizedbyitsconceptofholism,theprincipleofsyndromeidentificationinclinicaldiagnosis/treatment,itsherbalcompoundmedicationinpharmacotherapyanditscurativeeffectdemonstratedinmedicalpracticesoverthousandsofyearsinChina.However,itsbasictheoryislackingscientificproof,andthemechanismofactionsofherbalcomponentsisyettobeclarifiedbymodernscienceandtechnology.MedicinalChemistryemphasizesoncultivatingskillsandteachingrelevantknowledgeintheareaofdrugdiscovery/synthesisandidentificationofmechanismofactionsofnovelcompounds,soIfeelthatbytakingthisprogram,IwillbeabletoparticipateinthediscoveryofmechanismofactionsofChineseherbalmedicinesandtheclarificationofmeaningsofTCMtheory.MyundergraduatestudyinBiochemistryintheUniversityofXXhelpedmelaidfirmfoundationinfundamentalsforadvancedstudiesinmedicinalchemistry.ManycoursesItookduringtheundergradstudyhadlabcomponents,yetIenjoyedtheorganiclabsthemostbecausefirstly,itwasfascinatingtoreactdifferentchemicalswithoneanotherinspecificordersandobservetheformationofnewcompound;secondly,differentfromsomeotherlabswhichrequiremetohavelabpartners,theorganiclabinstructorencouragedustoworkindependently.AtfirstIgotreallystressedupbecausetherewasatimelimittofinisheachexperimentandIwasnotsurewhetherIcouldgeteverythingdonecorrectlyonmyown;yetafterafewsessions,Igotusedtoandstartedtoenjoyworkingandthinkingindependentlyandselfconfidencealsostartedtobuildup.Anotherexperiencethatservedtoconsolidatemydeterminationinpursuingmedicinalchemistryisthatduringmyundergraduatestudy,ItookacoursenamedEnvironmentalandNaturalProductsBiochemistrywhichnotonlygavemegeneralinformationaboutthefunctions,distributionsandenvironmentalactionsofavarietyofnaturalcompoundsisolatedfromplantsandotherorganisms,butalsohelpedmediscoverwheremytrueinterestlies.However,therewasnolaboratoryassociatedwiththatcourseinouruniversity,andasaresult,Ididn’tmanagetofindachancetotrymyhandsonsynthesizingthosenaturalcompounds.Ihavebeenlookingforwardtoparticipateinresearchesrelatedtodrugdiscovery/synthesissincethen.MygraduatestudyinPharmaceuticalSciencesinXXUniversitynotonlyprovidedmewithmoredetailedknowledgeindrugdiscovery,butalsohelpedmedevelopvaluableresearchskillswhichwillhelpmesucceedinthemedicinalchemistryprogram.Duringmystudyinthisuniversity,Iparticipatedinaresearchprojectconcernedaboutimprovingphysicochemicalpropertiesofapoorlysolublecarboxylicaciddrug(gemfibrozil)bysaltformation,whichgenerallyinvolvedsynthesizingaseriesofaminesaltsofgemfibrozil,comparingvariousproperties(includesaturatedsolubility,IDR,meltingpointsbyDSC,particlesize,surfacetensionandcrystalhabits)oftheresultingsaltformsandexploringpossibletrendsexistedamongtheseproperties(attheendoftheprojectIsuccessfullydiscoveredanegativecorrelationbetweenlogsaltsolubilityandsaltmeltingpoints;positivecorrelationsbetweenlogsaltsolubilityandpHmax/logIDR;andanegativecorrelationbetweennumberofringspresentedinthecounterionsandthesolubilityofthecorrespondingsaltformsofgemfibrozil).Althoughthisprojectisnotdirectlyrelatedtomedicinalchemistry,ithelpedtogreatlyenhancemyresearchskills,whichincludedoingliteraturereviewonunfamiliarconcept,thenquicklyinternalizingthesenewconceptsandapplyingthemontotheexperimentsthatIwasdoing;makingrealisticworkplans;effectivelymanagingmytimeduringeachlabsessionandaccomplishingeverymeasurementasaccuratelyasIcouldtoavoidrepeatingexperimentwhichwouldputmeundertheriskoffallingbehindmyschedule.Theprojectreportwritingimprovedmyabilitytocriticallyanalyzeandcompareliteraturefindingsanddrawreasonableconclusionsfrommyowndatabasedontheknowledgeobtainedfrompublishedpapers.Theundergraduateandgraduatestudyexperienceshavetemperedmeasaself-reliantpersonwhoisalwaysreadytoapproachproblemsindependentlywithconfidence;cultivatedmyinterestindrugdiscovery/synthesis;andhelpedmedevelopresearchskillsthatareessentialforsuccessinmedicinalchemistryprogram.……此处为申请学校及教授信息Ibelievemyacademicbackgroundhasprovidedmewithafirmfoundationformyfuturesuccessinthisacademicdiscipline,andIsincerelywishtobeacceptedintothisprogramsoIcanequipmyselfwithcrucialskillsandknowledgeneededtomakecontributiontobothdrugdiscovery(synthesisanddiscoveryofmechanismsofactionofnovelcompounds)andintegrationofTCMwithmodernscience.