NF-κB信号转导通路和肿瘤发生、转移关系的研究进展

[e-mail]021-631383415211NF-KBNF-KBNF-KBNF-KBNF-KBNF-KBNF-KBnucIearfactor-KBBKKBGGGACTTTCCNF-KBNF-KBNF-KB!#!$NF-KBwntnocthhedgehogNF-kBIL-1IL-2IL-6IL-12TNF-xLTxLT?GM-CSFIL-8MIP-1xMCP1ICAMVCAME-seIectinSAA1TBNF-KBReIAp65c-ReIReIBNFKB1p50NFKB2p52NF-KBp65p50p65/p50NF-KBInhibitorofkappaBI-KBsNF-KBI-KBxI-KB?I-KByI-KBSI-KBxNF-KBNF-KBNF-KBNF-KBTNFxI-KBxSer32Ser36I-KBxATP26SNF-KB5'-GGGACTTTCC-3'I-KBxI-KBxI-KBxIKKIKK3IKK1/IKKxIKK2/IKK?IKK3/IKKyTNFxNF-KBTNFxTNFTNFTNFreceptor-associateddeathdomainproteinTRADDTRADDTNF2TNFreceptor-associatedfactor2TRAF2NF-KBNIKIKK1IKK2MAPNIK/MEKK1I-KBxI-KB?A20NF-KBTRAF-2NF-KBTRAF2NF-KBA20TNFIL-1NF-KBNF-KBTBNFKBNF-KBNF-KB2!#!$NF-KBNF-KBNF-KBRas3NF-KBRasc-MycNF-KBNF-KBBiswasEpidermaIgrowthfactorEGFNF-KB4EpidermaIgrowthfactorreceptorEGFRNF-KB5HER2352007151BeijingJournaIofStomatoIogyFebruary2007VoI.15No.1HER2NF-!B6NF-!BIL-lIL-6IL-8GM-CSF7NF-!BNF-!BTNFTNFR-associatedfactorTRAFTRAFlTRAF2inhibitor-of-apoptosisIAPc-IAPlc-IAP2Bci-2caspase-88NF-!B9Rasp53NF-!BNF-!BNF-kappaB-inducibieDED-containingproteinNDEDTNFcaspase-8caspase-8l0ChenNF-!BTNF-llNF!BSurvivinCyciinDl2Cyciooxygenase-2##-Giutamyicysteine#-GCSl2NF-!BNF-!BmatrixmetaiioproteinasesMMPurokinase-typepiasminogenactivatoruPA8Interieukin8IL-8OsteopontinOPNNF-!BMTl-MMPMMP2l3NF-!Bmitogen-activatedproteinkinaseMAPKIL-8vascuiarendotheiiaigrowthfactorVEGFl4NF-!BNF-!BICAM-lVCAM-lELAM-linducibienitricoxidesynthaseiNOSNF-!BNF-!BReiApl05/p50I-!Bl5NF-!Bl6NakayamaNF-!Bp65IKKl7-lBreastcancermetastasissuppressorlBRMSlNF-!BI!BuPAl8HeibigNF-!B4chemokinereceptorCXCR4l9NF-!B20Tip60$-catenin-reptinKAIlNF-!B2lNF-!B20%PidgeoniipopoiysaccharideLPSNF-!BMMP2VEGF22Gretencoiitis-associatedcancerCACNF-!BIKK$IKK$CACIKK$IL-lIL-l$IL-6KCMIP2TNFCOX2ICAM-l23LuoNF-!BTNFTRAILNF-!B24HahmHpNF-!B-2COX-2IL-8Hp25KimHpAGSSNU-484NF-!BHp26EiiPikarskyNF-!B27NF-!BNF-!BNF!BNF-!B452007l5lBeijingJournaiofStomatoiogyFebruary2007Voi.l5No.lNF-!B1GhoshSKarinM.MissingpiecesintheNF-kappaBpuzzIe.CeII2002109SuppI81-96.2BhartiACAggarwaIBB.NucIearfactor-kappaBandcanceritsroIeinpreventionandtherapy.BiochemPharmacoI2002645-6883-888.3AggarwaIBB.NucIearfactor-kappaBtheenemywithin.CancerCeII200463203-208.4BiswasDKCruzAPGansbergerEetaI.EpidermaIgrowthfactor-inducednucIearfactorkappaBactivationAmajorpathwayofceII-cycIeprogressioninestrogen-receptornegativebreastcancerceIIs.ProcNatIAcadSciUSA200097158542-8547.5EtienneMCFormentoJLLebrun-FrenayCetaI.EpidermaIgrowthfactorreceptorandIabeIingindexareindependentprognosticfactorsingIiaItumoroutcome.CIinCancerRes19984102383-2390.6Bhat-NakshatriPSweeneyCJNakshatriH.IdentificationofsignaItransductionpathwaysinvoIvedinconstitutiveNF-kappaBactivationinbreastcancerceIIs.Oncogene200221132066-2078.7DufferDCChenZDongGetaI.Expressionofadominant-negativemutantinhibitor-kappaBaIphaofnucIearfactor-kappaBinhumanheadandnecksguamousceIIcarcinomainhibitssurvivaIproinfIammatorycytokineexpressionandtumorgrowthinvivo.CancerRes199959143468-3474.8WangCYMayoMWKomeIukRGetaI.NF-kappaBantiapoptosisinductionofTRAF1andTRAF2andc-IAP1andc-IAP2tosuppresscaspase-8activation.Science199828153831680-1683.9DongGLoukinovaEChenZetaI.MoIecuIarprofiIingoftransformedandmetastaticmurinesguamouscarcinomaceIIsbydifferentiaIdispIayandcDNAmicroarrayreveaIsaIteredexpressionofmuItipIegenesreIatedtogrowthapoptosisangiogenesisandtheNF-kBsignaIpathway.CanRes200161124797-4808.10YouZOuyangHLopatinDetaI.NucIearfactor-kappaB-inducibIedeatheffectordomain-containingproteinsuppressestumornecrosisfactor-mediatedapoptosisbyinhibitingcaspase-8activity.JBioIChem20012762826398-26340.11ChenSFribeyAWangCY.Potentiationoftumornecrosisfactor-mediatedapoptosisoforaIsguamousceIIcarcinomaceIIsbyadenovirus-mediatedgenestransferofNF-!Binhibitor.JDentRes200281298-102.12ShishodiaSAggarwaIBB.NucIearfactor-kappaBactivationaguestionofIifeordeath.JBiochemMoIBioI200235128-40.13PhiIipSBuIbuIeAKunduGC.MatrixmetaIIoproteinase-2mechanismandreguIationofNF-kappaB-mediatedactivationanditsroIeinceIImotiIityandECM-invasion.GIycoconjJ2004218-9429-241.14BancroftCCChenZDongGetaI.CoexpressionofproangiogenicfactorsIL-8andVEGFbyhumanheadandnecksguamousceIIcarcinomainvoIvescoactivationbyMEK-MAPKandIKK-NF-kappaBsignaIpathways.CIinCancerRes200172435-442.15McNuItySETohidianNBMeyskensFLJr.ReIAp50andinhibitorofkappaBaIphaareeIevatedinhumanmetastaticmeIanomaceIIsandrespondaberrantIytouItravioIetIightB.PigmentCeIIRes2001146456-465.16HuangSDeGuzmanABucanaCDetaI.NucIearfactor-kappaBactivitycorreIateswithgrowthangiogenesisandmetastasisofhumanmeIanomaceIIsinnudemice.CIinCancerRes2000662573-2581.17NakayamaHIkebeTBeppuMetaI.HighexpressionIeveIsofnucIearfactorkappaBIkappaBkinaseaIphaandAktkinaseinsguamousceIIcarcinomaoftheoraIcavity.Cancer200192123037-3044.18CicekMFukuyamaRWeIchDRetaI.Breastcancermetastasissuppressor1inhibitsgeneexpressionbytargetingnucIearfactor-kappaBactivity.CancerRes20056593586-3595.19HeIbigGChristophersonKW2ndBhat-NakshatriPetaI.NF-kappaBpromotesbreastcancerceIImigrationandmetastasisbyinducingtheexpressionoftheche