XiaoWangDepartmentofXXXX,XXXXUniversitySchoolofMedicine,Guangzhou,Guangdong,ChinaTel:XXXX;Fax:XXXXE-mailaddress:XXXXJuly8,2005DearEditor,Wewouldliketoresubmittherevisedmanuscriptentitled“XXXXXX”forconsiderationbyXXXX(journalname).Wewouldliketothankthereviewersforthoroughlyreviewingourmanuscriptandmakingmanythoughtfulcomments.Wewereverypleasedtoseethatallthreereviewersrecognizedthenoveltyandpotentialsignificanceofourwork.Wehaveaddedsignificantnewdata,describedindetailbelow,andrevisedthemanuscripttoaddressreviewers’comments.Hereareourpoint-by-pointresponses:Reviewer#1:Comment1:“Fig.1.Ithinkthedata……………?”(thequestionfromreviewer)Answer:Wehaveused………(Fig.1B)(showwhatyoudidtoanswertheirquestionsordirectlyexplainifyoudon’tneedtodoanything).Comment2:“……………..”Answer:Wehavenowtestedthe……………(Fig.S3G).…………………………….Reviewer#2:Comment1:“…………………”(thequestionfromreviewer)Answer:Wehaveused………(Fig.1B)(showwhatyoudidtoanswertheirquestionsordirectlyexplainifyoudon’tneedtodoanything).………………….Thankyouforyourconsiderationofourmanuscript.Yourssincerely,XiaoWang,Ph.D.