阴道微生态与妇科肿瘤

【】2013-03-27【】【】[e-mail][e-mail]1005-376X201307-0866-02【】1211．1000342．418000【】、、。、。【】【】Ｒ75【】AStudyofvaginalmicroecologyandgynecologicaltumorsTIANXiaoying12LIAOQin-ping21．PekingUniversityFirstHospitalBeijing100034China2．HuaihuaMedicalCollegeHuaihua418000Chi-na【Abstract】Vaginalmicroecologyareimportantindicatorsofthehealthofthefemalereproductivesystem．Avarietyoffactorscanaffectvaginalmicro-ecologicalbalanceresultingintheinvasionsofendogenousandexogenousmicroorganismsintovaginaandcausingdiseasessuchasvaginitischroniccervicitiscervicalandovariancancerfallopiantubecancerandotherdiseaseswhichseriouslyaffectpatients’healthandqualityoflife．Clinicallycommongynecologicaltumorsaregenerallyaccompanieswithobviousimbalanceinvaginalmicro-ecosystems．Tounderstandandpayattentiontothebalanceofmicro-ecologicalenvironmentofthevaginaifofgreatsignificanceforthepreventionandtreatmentofgynecologicalcancersaswellasthepost-surgeryrecoveryandcare【Keywords】VaginalmicrobialecologyGynecologiconcologyＲeproductivetractinfections、。、、。、。11892DED-EＲLEIN。、、、、、、、、、、、、50%～80%。、、、1。22．1。。。2．2。BOＲIS2。pH3．8～4．4、3。H2O2、。H2O2H2O2H2O24H2O25。、6。66820137257ChineseJournalofMicroecologyJul．2013Vol．25No．72．3SIgA。、、。。2．3．1、。、TNF-α、IL-1、IL-6、IL-8、。7HD5。8MBL。2．3．2TB。TTh1Th2。IL-2、IFN-γ、IL-12TNF-βTh1NKIL-4、IL-5、IL-6、IL-10IL-13Th2B。。FＲATTI9IFN-γ、IL-5、IL-2、IL-13。IgG、IgM、IgAIgE。HEIN10IgAIgG。3、11。、。KOＲSHUNOV12HPVCINCIN。13、。、、1415。16。BUDAGOV17。。4。、、、、。。【】1LIUZhao-huiLIAOQin-ping．VaginalinfectionsdiseasediagnosisandtreatmentstrategiesM．BeijingPeople'sMedicalPublishingHouse20091-3．inChinese．M．20091-3．2McGＲOAＲTYJATOMECZEKLPONDDGetal．Hydrogenperox-ideproductionbylactobacillusspeciescorrelationwithsusceptibititytothespermicidalcompoundnonoxynol-9J．JInfectDis200116561142-1144．3VOＲAVUTHIKUNCHAISPBILASOISSUPAMALAO．AntagonisticactivityagainstpathogenicbacteriabyhumanvaginallactobacilliJ．Anaerobe2006125-6221-226．4SETHISDASASHAＲMAM．InhibitionofGardnerellavaginalibylactobacilliJ．IntJGynaecolObstetr2006932158-159．5ZHANGYanSONGLei．Lactobacillusbacterialvaginosisrelationsre-searchprogressJ．ChinJClinObstetrGynecol200782150-152．inChinese．J．200782150-152．6McFAＲLANDLV．NormalfloradiversityandfunctionsJ．MicrobialEcolHealthDis2000124193-207．7ZHANGDaiLIUZhao-huiLIAOQin-ping．Lowergenitaltractinfec-tioninpatientswithvaginallocalimmunestatusofresearchJ．ChinaObstetrGynecol200944113-15．inChinese．J．200944113-15．8LIUFeiLIAOQin-pingLIUZhao-hui．GenitalCandidainpatientswithvaginalmannosebindinglectindetectionandgenepolymorphismanalysisJ．ProgObstetrGynecol2005145371-374．．J．2005145371-374．76820137257ChineseJournalofMicroecologyJul．2013Vol．25No．7。。。、、。SPFSpecificpathogenfreeSPF。。。。。。。。【】1ELSVANNOODANNEVＲIEZEMAXNIEUWDOＲPetal．Duode-nalinfusionofdonorfecesforrecurrentclostridiumdifficileJ．NEnglJMed20133685407-415．2BＲANDTLJAＲONIADISOCMELLOWMetal．Long-termfollow-upofcobnoscopicfecalmicrobiotatransplantforrecurrentclostridiumdiffcileinfectionJ．AmJGastrocenteroic201210771079-1087．3BOWENTAJrMANSBEＲGEＲAＲJrLYKISLE．Pseudomembra-neousenterocolitismechanismforrestoringfloralhomeosiasisJ．AmSurg1981474178-183．4BOＲODYTJKHOＲUTSA．Fecalmicrbiotatransplantionandemer-gingapplicationsJ．NatＲevGastroenterolHepatol20129288-96．5ZHANGFa-ming．Themedicalhistoryanditsclinicalapplicationin1700J．JHubeiUnivNationalitMedEdit20122931-4．inChinese．1700J．20122931-4．6VＲIEZEAVANNEHOLLEMANFetal．Transferofintestinalmi-crobiotafromleandonorsincreasesinsulinsensitivityinsubjectswithmetabolicsyndromeJ．Gastroenterology20121434913-916．7WANGShi-rong．TheoverviewresearchandapplicationprospectofMi-crobiologyJ．ChinJMicroecol2013255617-619．inChinese．J．2013．255617-619．．8GEHongDongjin．ElbowbackupurgentprescriptionVolume2M．TianjinTianjinScience＆TechnologyPress200036．inChi-nese．M．200036．9LIShi-zhen．CompendiumofmateriamedicaVol52M．BeijingHuaxiaPublishingHouse20111921-1923．inChinese．52M．20111921-櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆1923．8679FＲATTIＲAGHANNOUMMAEDWAＲDSJEJretal．Gammain-terferonprotectsendothelialcellsfromdamagebyCandidaalbicansbyinhibitingendothelialcellphagocytosisJ．InfectImmun199664114714-4718．10HEINMPETEＲSENACHELMINGＲBetal．ImmunoglobulinlevelsandphagocytesinthecervicalmucusplugattermofpregnancyJ．ActaObstetGynecolScand2005848734-742．11LIJi-mingHUANGGe-lingLIZhietal．4816casesofgynecologicoutpatientwomenvaginamicroecologicalconditionanalysisJ．ChinJMicroecol2011239848-849．inChinese．4816J．2011239848-849．12KOＲSHUNOVVMKAFAＲSKAIALIBAGIＲOVAMSHetal．TheeffectofSolcoTrichovaconthevaginalmicrofloraofpatientswithapapillomavirusinfectionassociatedwithacervicalintraepithelialneo-plasmJ．ZhMikrobiolEpidemiolImmunobiol1994513-17．13LUCai-hongLIBao-hongLIXiao-bin．DistributioncharacteristicsofpatientswithcervicalcancervaginalmicroorganismsJJChinaMedUniv2011403267-271．inChinese．J．2011403267-271．14MAＲOTTAFNAITOYMINELLIEeta1．Chemopreventiveeffectofaprobioticpreparationonthedevelopmentofpreneoplasticandneo-plasticcoloniclesionsanexperimentalstudyJ．Hepatogastroenterolo-gy200350541914-1918．15KITAZAWAHWATANABEHSHIMOSATOTeta1．Im