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1992414(,43003。),,RNA,,、、,。RNA,DNA,mRNA,。RNA,,。、。10,。DNA,(reversegeneties)「,。,,,“”,,。。,,,mieRNA(mRNAinterferingcom-pl。ntoryRNA)“”[21,RNA〔“],[`1〔”]。RNA,.”`￡·“{。,〕。NA,。JefferyTHH60cmycbpcmy。,,。RNA5P3mRNA,.1959,skulskiD。`“1ccylinmRNA,cyolln。。(trypanosomia-515);。RNA〔’`]。,J“kleH.,NA“shive:er”〔’2’,(MBP),“5,~、,,。,`”,`“1;,,、、、。NA:Tn;;;,:。11RNA,·ONA,。:①,II。IRNASD()AuG,,lmNA,。RNA,,mNR;②l。E:·icolticRNA(t:aeriptinhibitorycomtrQyA)RNA(cAMp),,NA,hRo.③,E·coilcolEIFl).。.RNAI(RN,A)RNaH,,DNA。,,.:①,(yceXonl(’xonZ(TG),c。RNA,AUGmRNA[`1.cmy。,cy’ccX。l,c`。RNA,,Bikttcyc,。I。“shiv;rc:”MEP,MEpMBpmRNA2,p3(3~7),r’“,。,。②,mNANRANA。UlonRNp(smallnuelearribonueloo-pt)UIRNA5`mRNAl5’(mo5/。。tn),,。U1RNA、5’8Ul:nRP,。rNA。mRNA。③,RN,U,tcRNA(tran:Iationeont:01EN)t“J,mNAp。,;④RNA:mA,。A52.5`,hIJL;}。RNA,。:,,。WelntarubHMzIantJG.HSv.,TK,,.。L〔`]。,RNA,acitn,actin,,。,RNA,。“NRA”(ribozyme)RNA,GUCCUCRNA。mRNA,“ribozyme”,ribozymeRNAm-RNA,。RNA,,,〔’”,”,`],(MMTvLTR);IA(HMTIA)zn“。RNA,,DNA(15~25bp)。DNA,。,RemmesonK,CD3HIVIevnRNA,[5〕oRNARNA。、RNA,:①mRNA,mRNA,RNA,。②RNA,。CottenMU7SnNRPmRNA,15~75,。,SD;,5`,3`。③,,,。(undecyl)5`,,MDCKt`“],.MOmsonJLPSIL-1,98,,〔2。]。a,。Proflavine,PorPhyrins,Psorale。1534356879011.OnJ4tOUO.,.J....,.,〔“`’(aeridine),。EDT-AFe(I)porphyrine(I),ophe-nantroineCu(I),mRNA,。polyLL929vSV。DNA。,,。EDTAe(),DNA(),。,,。20211WeintraubHM.SeiAm,1990:262:342GreenPJetal.AnnuRevBioehem,1986:55:569KulkaMeta!.ProeNat}AeadSeiUSA,1089;56(18):6568KabanovAVetal.FEBSLett,1990:259(2):327RenneisenKetal,JBiolChem,1990;265(27):16337.,1990:2:70SkeikyYAWetaj.JMolBioj,1990:213(r):53RrystalGWetal.MolCellBiol,1990;10(8):4150TortoraGetal.ProeNat]AeadSeiUSA,1990:87(2):705JaskulskiDetal.Seienee,1988;240:1544RiveraRTetal.JCellBiol,1989;208(6):2423TosioMeta!.EMBOJ,1990;9(2):401KrolAeta].Nature,1988;333:8665imonsRW.Gene,1958;72(12):35KumeTUetal.JMolBiol,1988;202:779Heywood5etal.NueleieAeidsRes,198614:6771.,1989;16(4)293TomokoKIetal.MolCellBiol,1955;s(12):5545CH.NGSLCetal.ProeNatlAeadSeiUSA,1959;56(2):10006MansonJetal.LymPhokineRes,1990;9:35BoidotFMetal.Gene,xgss;72(12):361(19910613)`。.```.`.``.`.`.`````,.`.``,,..`,。,..``.。,``,`030cerbB2〔)/…//,2992,37(1)3335,cerbB2,,。,c-erbB2。、16.9(56.3),,,。、。,。,CerbB2,,,。,cerbB2(KM93、KM231SCC),。.()154