PPARγ激动剂对近端肾小管上皮细胞结缔组织生长因子表

中国协和医科大学博士学位论文PPARγ激动剂对近端肾小管上皮细胞结缔组织生长因子表达的影响姓名：秦岩申请学位级别：博士专业：内科肾脏病学指导教师：李学旺20040501PPARγ激动剂对近端肾小管上皮细胞结缔组织生长因子表达的影响作者：秦岩学位授予单位：中国协和医科大学参考文献(100条)1.参考文献2.BaderR.BaderH.CrundKEStructureandfunctionofthekidneyindiabeticglomerulosclerosis:Correlationbetweenmorphplogicalandfunctionalparameters19803.GandhiM.OlsinJL.MeyerTWContributionoftubularinjurytolossofremnantkidneyfunction19984.ZiyadehFN.SharmaKRoleoftransforminggrowthfactor-betaindiabeticglomerulosclerosisandrenalhypertrophy19955.ReevesWB.AndreoliTETransforminggrowthfactorbetacontributestoprogressivediabeticnephropathy20006.IsakaY.TsujieM.AndoYTransforminggrowthfactor-b,antisenseoligodeoxynucleotidesblockinterstitialfibrosisinunilateralureteralobstruction20007.ShannaK.JinYL.GuoJNeutralizationofTGF-betabyanti-TGF-betaantibodyattenuateskidneyhypertrophyandtheenhancedextracellularmatrixgeneexpressioninSTZ-induceddiabeticmice19968.BottingerEP.JakubczakJL.HainesDCTransgenicmiceoverexpressingadominantnegativemutanttypeⅡtransforminggrowthfactorbetareceptorshowenhancedtumorigenesisinthemammaryglandandlunginresponsetothecarcinogen7,12-dimethylbenz-[a]-anthracene19979.WahabNA.WestonBS.RobertsTConnectivetissuegrowthfactorandregulationofthemesangialcellcycle:roleincellularhypertrophy200210.YokoiH.SugawaraA.MukoyamaMRoleofconnectivetissuegrowthfactorinprofibroticactionoftransforminggrowthfactor-beta:apotentialtargetforpreventingrenalfibrosis2001(z1)11.DuncanMR.FrazierKS.AbramsonSConnectivetissuegrowthfactormediatestransforminggrowthfactorbeta-inducedcollagensynthesis:downregulationbycAMP199912.WangS.DenichiloM.BrubakerCConnectivetissuegrowthfactorintubulointerstitialinjuryofdiabeticnephropathy200113.WahabNA.MasonRMConnectivetissuegrowthfactorandrenaldisease:someanswers14.79morequestion200415.RiserBL.DenichiloM.CortesPRegulationofconnectivetissuegrowthfactoractivityinculturedratmesangialcellsanditsexpressioninexperimentaldiabeticglomerulosclerosis200016.RiserBL.CortesPConnectivetissuegrowthfactoranditsregulation:Anewelementindiabeticglomerulosclerosis200117.LiuBC.SunJ.ChenQRoleofconnectivetissuegrowthfactorinmediatinghypertrophyofhumanproximaltubularcellsinducedbyangiotensinⅡ2003(06)18.YokoiH.MukoyamaM.SugawaraARoleofconnectivetissuegrowthfactorinfibronectinexpressionandtubulointerstitialfibrosis2002(05)19.FrazierKS.ParedesA.DubeP.StyerEConnectivetissuegrowthfactorexpressionintheratremnantkidneymodelandassociationwithtubularepithelialcellsundergoingtransdifferentiation2000(04)20.GhoshAK.BhattacharyyaS.LakosGDisruptionoftransforminggrowthfactorbetasignalingandprofibroticresponsesinnormalskinfibroblastsbyperoxisomeproliferatoractivatedreceptorgamma2004(04)21.KawaguchiK.SakaidaI.TsuchiyaMPioglitazonepreventshepaticsteatosis,fibrosis,andenzyme-alteredlesionsinratlivercirrhosisinducedbyacholine-deficientL-aminoacid-defineddiet2004(01)22.BorkPThemodulararchitectureofanewfamilyofgrowthregulatorsrelatedtoconnectivetissuegrowthfactor199323.SatoS.NagaokaT.HasegawaMSerumlevelsofconnectivetissuegrowthfactorareelevatedinpatientswithsystemicsclerosis:associationwithextentofskinsclerosisandseverityofpulmonaryfibrosis2000(01)24.GrotendorstGR.OkochiH.HayashiNAnoveltransforminggrowthfactorbetaresponseelementcontrolstheexpressionoftheconnectivetissuegrowthfactorgene1996(04)25.GoldschmedingR.AtenJ.ItoYConnectivetissuegrowthfactor:justanotherfactorinrenalfibrosis200026.GuptaS.ClarksonMR.DugganJConnectivetissuegrowthfactor:potentialroleinglomerulosclerosisandtubulointerstitialfibrosis200027.ItoY.AtenJ.BendeRJExpressionofconnectivetissuegrowthfactorinhumanrenalfibrosis1998(04)28.陈丽萌.李学旺.黄利伟.李艳.段琳.张小娟2型糖尿病小鼠(KKAy)动物模型的鉴定和早期肾脏病理改变[期刊论文]-中国医学科学院学报2002(1)29.WangS.DenichiloM.BrubakerC.HirschbergRConnectivetissuegrowthfactorintubulointerstitialinjuryofdiabeticnephropathy2001(01)30.PaueksakonP.ReveloMP.MaLJMicroangiopathicinjuryandaugmentedPAI-1inhumandiabeticnephropathy2002(06)31.ZhengF.FornoniA.ElliotSJUpregulationoftypeⅠcollagenbyTGF-betainmesangialcellsisblockedbyPPARgammaactivation2002(04)32.WangSN.LaPageJ.HirschbergRRoleofglomerularultrafiltrationofgrowthfactorsinprogressiveinterstitialfibrosisindiabeticnephropathy2000(03)33.RyanMJ.JohnsonG.KirkJHK-2:animmortalizedproximaltubuleepithelialcelllinefromnormaladulthumankidney1994(01)34.ClemasJ.LeibowitzMD.ElbrechtAAPPARmutantservesasadominantnegativeinhibitorofPPARsignalingandislocalizedinthenucleus200035.TontonozP.NagyL.AlvarezJGPPARpromotesmonocyte/macrophagedifferentiationanduptakeofoxidizedLDL199836.ChinettiG.GriglioS.AntonucciMActivationofproliferator-activatedreceptorsandinducesapoptosisofhumanmonocyte-derivedmacrophages199837.AkiyamaT.BaumannCT.SakaiASelectiveIntranuclearRedistributionofPPARIsoformsbyRXRα2002(04)38.NicholasSB.KawanoY.WakinoSExpressionandFunctionofPeroxisomeProliferatorActivatedReceptor-ginMesangialCells200139.IssemannI.GreenSActivationofthesteroidhormonereceptorsuperfamilybyperoxisomeproliferators1990(6294)40.ZhuY.QiC.KorenbergJRStructuralorganizationofmouseperoxisomeproliferator-activatedreceptorγ(mPPARy)gene:Alternativeprom