(aged65yearsandabove).ThediseasehasahugeimpactonPublicCompanyhealth.InfluenzaAvirusposesagreaterriskascomparedtotheinfluenzaBvirus.TheBvirusisresponsiblefor20%to25%ofinfectionsglobally.Propercollection,storageandtransportofrespiratoryspecimensaretheessentialfirststepforlaboratorydetectionofinfluenzavirusinfections.Laboratoryconfirmationofinfluenzavirusfromthroat,nasalandnasopharyngealsecretionsortrachealaspirateorwashingsiscommonlyperformedusingdirectantigendetection,virusisolation,ordetectionofinfluenza-specificRNAbyreversetranscriptase-polymerasechainreaction(RT-PCR).’sseasonalinfluenzavaccinationforpreventionandcontrolofseasonalinfluenza;andthedemandcreatedforinfluenzadiagnosisinthefluseason.FigurePictureofInfluenzaDiagnosticsSource:QYRHealthcare&PharmaResearchCenter,Oct.20161.2InfluenzaDiagnosticsSegmentbyTypes1.2.1GlobalRevenueMarketShareofInfluenzaDiagnosticsbyTypesin2015FigureGlobalRevenueMarketShareofInfluenzaDiagnosticsbyTypesin2015)onlyinfluenzaAviruses;2)bothinfluenzaAandBviruses,butnotdistinguishbetweenthetwotypes;or3)bothinfluenzaAandBanddistinguishbetweenthetwo.NoneoftherapidinfluenzadiagnostictestsprovideanyinformationaboutinfluenzaAvirussubtypes.Thetypesofspecimensacceptableforuse(i.e.,throat,nasopharyngeal,ornasalaspirates,swabs,orwashes)alsovarybytest.FigureProductPictureofRIDT52.23%29.80%11.26%6.71%2015(e.g.influenzaA,influenzaBandRSVinthesametest),quantification(viralloadcount),anddetection.Additionally,comparedtophysicianclinicalmanagement,rapidantigentestingandotherpoint-of-caretestingmethods,real-timePCRhasdemonstratedimproveddetectionofinfluenza.Thespecificityand,inparticular,thesensitivityofrapidinfluenzadiagnostictestsarelowerthanforviralcultureandRT-PCRandvarybytest.Becauseofthelowersensitivityoftherapidinfluenzadiagnostictests,physiciansshouldconsiderconfirmingnegativetestswithRT-PCR,viralcultureorothermeans,especiallyinhospitalizedpatientsorduringsuspectedinstitutionalinfluenzaoutbreaksbecauseofthepossibilityoffalse-negativerapidtestresults,especiallyduringperiodsofpeakcommunityinfluenzaactivity.FigureProductPictureofRT-PCR’sinfluenzavaccine.Duringoutbreaksofinfluenza-likeillness,viralculturealsocanhelpidentifyothercausesofillness.FigureProductPictureofCellCultureSource:QYRHealthcare&PharmaResearchCenter,Oct.20161.3InfluenzaDiagnosticsSegmentbyApplications(e.g.,hospitals,nursinghome,cruiseship)however,testingforinfluenzacanbeveryhelpfulindeterminingifinfluenzaisthecauseoftheoutbreak.FigureHospitalsExamples60.99%28.69%10.32%2015