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8320066ChinJContempPediatrVol.8No.3Jun.2006[]2005-12-02;[]2006-03-28[](20040421)[],,,:1,1,1,2(1.,518020;2.,10084)[](MAS)(regionaloxygensatu2ration,rSO2)MASTSNIR23,1,3,5,7d,MASrSO21(58.374.12vs60.432.85)3(57.762.33vs60.173.46)(P0.05);MAS1,3,5rSO2,MASrSO21,3,5(P0.05)MASHIEHIE,rSO21(P0.05),2,3,5(57.603.60vs53.364.48;55.602.35vs51.363.20;56.802.78vs53.225.10)(P0.05)MASrSO2,[,2006,8(3):191-194][],;;[]R722[]A[]1008-8830(2006)03-0191-04RegionalcerebraloxygensaturationinneonateswithmeconiumaspirationsyndromeLIZhi2Guang,YEWen2Fang,WENFei2Qiu,DINGHai2Shu.DivisionofNeonatology,SecondAffiliatedHospital,JinanUniversity,Shenzhen,Guangdong518020,China(Email:lizg88@163.com)Abstract:ObjectiveThisstudyexaminedthechangesofregionalcerebraloxygensaturation(rSO2)bynoninvasivenearinfraredspectrophotometryinneonateswithmeconiumaspirationsyndrome(MAS).MethodsSeventy2threefullneonateswithMASweredividedintothreegroupsbyrespiratorysymptoms:asymptomaticgroup(group1,n=38),commongroup(group2,n=28)andseveregroup(group3,n=7).NearinfraredspectrophotometrywasusedtomeasurethecerebralrSO2ondays1,3,5and7afterbirth.Thirtyhealthyfull2termnewbornsservedastheControlgroup.ResultsThecerebralrSO2ofgroup1decreasedsignificantlycomparedwiththatoftheControlgroupbetweendays1and3(P0.05).ThecerebralrSO2ofgroup2orgroup3wassignificantlylowerthanthatofgroup1andtheControlgroupondays1,3and5(P0.05).TheMASpatientswithmildhypoxic2ischemicencephalopathy(HIE)hadsignificantlyhigherbrainrSO2levelsthanthosewithmediumorsevereHIEondays2,3and5(P0.05).ConclusionsThecerebralrSO2decreasedinneonateswithMAS.ThevaluesforrSO2correlatewiththeseverityofHIEinMASpatients.[ChinJContempPediatr,2006,8(3):191-194]Keywords:Regionaloxygensaturation,cerebral;Meconiumaspirationsyndrome;Neonate(meconiumaspirationsyn2drome,MAS),,,,(CMRO2)(SjvO2),,MAS,,,MAS(regionaloxygensaturation,rSO2),1918320066ChinJContempPediatrVol.8No.3Jun.200611.11.1.120031120041138,22,16,39.961.24(37.242.5),3239.5422.6g(25104170g);12(31.6%);1Apgar:031(2.6%),474(10.5%)35(28,7),24,11,40.081.52(3741),3365.14460.5g(25004250g);16(45.7%);1Apgar:036(17.1%),479(25.7%)30,:20,10;39.761.09(37.243),3319.5365.7g(30004150g);1.1.2MASMAS3[1]:;;;XMAS3:,,,X;,,MAS,,X,;MAS48h,(ARDS)(PPHN),X,1.21.2.1TSNIR23()20,40,60mm,1.2.2,5min,3min,,,1.2.3,1(68h)3,5,7,AgilentV24CSPO2;23dSonoSite180plusB1.3SPSS10.0,(xs),q;tP0.0522.1MAS,4(P0.05)MAS,SO2;(HIE)718.4%MAS,,HIE1450%,HIE571.4%2.21,3,5,7(P0.05)11(xs)n13572060.402.2159.402.9958.853.4259.802.891060.503.9761.703.9760.902.3859.202.533060.432.8560.173.4659.533.2259.602.752.3MASMAS1,3,5,7,MAS,2918320066ChinJContempPediatrVol.8No.3Jun.20062MAS(xs)n13573060.432.8560.173.4659.533.2259.602.75MAS3858.374.12a57.762.33b58.682.0858.942.22MAS2855.044.29a,c54.713.35a,c55.504.70a,c57.891.55MAS754.145.76a,c52.862.97a,c55.141.07a,c57.141.68b,aP0.01,bP0.05;MAS,cP0.013MAS(xs)n1235710HIE1756.475.0157.603.6055.602.3556.862.7857.601.9659.332.85HIE957.3111.253.364.4851.363.2053.225.1057.901.4559.555.29F0.5647.15315.175.6750.1950.017P0.050.050.050.050.050.05,,13rSO2(P0.01)1,3,5rSO2,MAS,rSO2(P0.01)rSO2,22.4MASMAS,BCT,HIE2635.6%2005HIE[2],HIE17HIE91,2,3,5,7,10rSO2,HIEHIE,rSO21(P0.05);2,3,5(P0.05);7,10(P0.05)34HIE,,,rSO249%55%,,rSO2,23(NIRS)(7001100mm)(oxygenatedhemoglobinHbO2)(de2oxygenatedhemoglobinHbR)(CBV),,,,[3],rSO2TSNIR23,1,3,5,7,rSO2,(P0.05),[47]Wolf[8]rSO2SPO2,SPO2,rSO2,rSO2SPO2(20%75%5%),MAS,,,,,,,;,(PPHN),;,,MAS,3918320066ChinJContempPediatrVol.8No.3Jun.2006,13drSO2MAS,rSO2,rSO2,MAS,,rSO2,MAS,,[9],MAS29%,NIRS,,,[10]MASHIErSO2,HIEHIEHIE,rSO21,HIE,,35,,rSO2;HIE4MASHIE,rSO2,2,rSO2,rSO255%,,MASrSO2,MAS,,,,;,rSO2,[][1],,.[M].3.:,2003,4292433.[2].[J].,2005,7(2):97298.[3],,,,.[J].,2004,10(2):52253.[4]CooperCE,ElwellCE,MeekJH,MatcherSJ,WyattJS,CopeM,DelpyDT.Thenoninvasivemeasurementofabsolutecerebraldeoxyhemoglobinconcentrationandmeanopticalpathlengthintheneonatalbrainbysecondderivativenearinfraredspectroscopy[J].PediatrRes,1996,39(1):32238[5]WyattJS.Cerebraloxygenationandhaemodynamicsinthefoetusandnewborninfant[J].PhilosTransRSocLondBBiolSci,1997,352(1354):6972700.[6]IsobeK,KusakaT,FujikawaY,OkuboK,NaganoK,YasudaS,etal.Measurementofcerebraloxygenationinneonatesafterva2ginaldeliveryandcesareansectionusingfull2spectrumnearinfra2redspectroscopy[J].CompBiochemPhysiolAMolIntegrPhysi2ol,2002,132(1):1332138.[7]HuangL,DingH,HouX,ZhouC,WangG,TianF.Assess2mentofthehypoxic2ischemicencephalopathyinneonatesusingnoninvasivenearinfraredspectroscopy[J].PhysiologicalMeas,2004,25(3):7492761.[8]WolfM,vonSiebenthalK,KeelM,DietzV,BaenzigerO,Buch2erHU.Tissueoxygensaturationmeasuredbynearinfraredspec2trophotometrycorrelateswitharterialoxygensaturationduringin2ducedoxygenationchangesinneonates[J].PhysiolMeas,2000,21(4):4812491.[9],.[J].,2000,2(5):3112314.[10],,,.[J].,2004,6(6):4812484.(:)491