oct4、sox、klf4和nanog基因简介

oct4sox2klf4nanog1Oct4Oct3POU5F1Oct3Oct4POUOct46(6p21.31)16.40kbmRNA(Isoform)Oct4Isoform154DNAPOU(octamermotif)DNAOct4Isoform1Oct4????BOYER623(3)5(3)miRNAOct4Oct4S0x2NanogLEFTY2EBAFCDX2HANDlDPPA4GJAlCONNEXIN43FOX01ACRIPTOT1)GFlZIC3Oct4Sox2NanogTgf-1](TDGFlLEFTY2EBAF)Wnt(DKKlFRA=r2)Oct4sox2NanogOct4Sox2NanogSTAT3JAK-STAT3????RODDASox2-Oct4NanogEsrrbRiflTAKAHASHIYAMANAKA[28]4Oct34Sox2c-MycKIf4NanogOct4Nanog[29|MASUI[30]Sox2Oct4Sox2Oct4Oct4Oct4Oct4Oct4LEENDERT1003439Oct4Oct4()Oct4Oct4Oct4Oct420102srysryXY1990srysryYSRY79DNAHMG1HMG2HMGbox(high-mobilitygroupbox)HMGboxHMGbox????sry-sox(sry-relatedHMGbox-containing)soxSRYHMG-boxSRYlsryHMG-box(50%)????1995YuancDNAsox2cDNA1996Collignonsry8.5cDNAsox2cDNA????sox23sox2soxHMG-boxtcfsoxsox2Sox2200432006Kazutoshi[1]Klf4Sox2Oct4c-MyciPS4Klf49q316.3kb5cDNA1413bp470;?klf44B3Klf4483Klf491%103[2]RNAKlf43.5kb53k[3]Klf41q28291533bp????Klf4Kruppel[5][2][6]Klf4KlfKlfKlf43DNADNADNA????Klf4iPSKlf4c-MycOct4Sox2[39];?Klf4Klf4ES[41];?Klf4p300[18]iPSKlf4Sox2Oct4c-MycKlf4Klf4[42]Klf4iPS????Klf4Oct4Klf4Oct4[1]Klf4p53c-Mycc-MycKlf4[43]Klf4c-MyciPSKlf4c-MyciPSc-MycKim[44]Oct4Klf4c-MyciPSSox2c-MycESiPSiPSShi[45]BIX-01294BayK8644Oct4/Klf4iPSOkita[46]c-MycOct4Klf4Sox2iPSiPSKlf4200942003MitsuiChambersNanogESCsNanogANTPNK1212p13~31cDNA2184305NanogESCs????ESCsOct4Sox2Nanog33ESCsESCsSox2NanogOct4Sox2Oct4ESCsNanogOct4ESCs?FoxD3Wingedhelix/forkheadESCsOct4NanogFoxD3ESCsOct4NanogNanogFoxD3Oct4NanogFoxD3NanogOct4Oct4ESCsFoxD3NanogNanogp53Nanog3NanogNanogNanogWnt3ESCsNanogOct4ESCsANanogLIF/gp130/JAK/STAT3Wnt3/activin/nodaOct4-Sox2NanogNanog????NanogNanogESCsWntSHHNotchNanogNanog193Nanog??NanogESCsNanogGDF3STELLAR12p12p13Nanog?BenPorathNanogNanogmESCsNanogCSCs?CSCsNanogCSCsNanog2011Nanog2008