靶点基因检测-肺癌-华大基因

50NSCLCSCLCNSCLCEGFRALKVEGFPDGFSCLCVEGFPDGFHer2KrasBevacizumabVEGFR1IHC1/2/3VEGFR2IHC1/2/3VEGFR3IHC1/2/3GefitinibErlotinibEGFRExon18-21()1/2/3EGFR(FQ-PCR)FQ-PCR1/2/3EGFRT790M(1/2/3K-rascode12,13()1/2/3K-ras(FQ-PCR)FQ-PCR1/2/3CetuximabPanitumumabEGFRFISH1/2/3EGFRIHC1/2/3K-rascode12,13()1/2/3K-ras(FQ-PCR)1/2/3BRAFExon15V600E1/2/3CrizotinibALKFISH1/2/3METFISH1/2/3ROS1FISH1/2/3AfatinibEGFRExon18-21()1/2/3EGFR(FQ-PCR)FQ-PCR1/2/3K-rascode12,13()1/2/3K-ras(FQ-PCR)FQ-PCR1/2/3HER2Exon201/2/3CeritinibALKFISH1/2/3TrastuzumabHER2Exon201/2/3VemurafenibBRAFExon15V600E1/2/3DabrafenibBRAFExon15V600E1/2/3CabozantinibRETFISH1/2/3RamucirumabVEGFR2IHC1/2/3PlatinumERCC1IHC1/2/3ERCC1(C118T)4ERCC2(Lys751Gln)4TPMT(TPMT*1,*2,*3A,*3B,*3C)4XRCC1(Arg399Gln)4GSTP1(Ile105Val)4GSTT14GSTM14K-rascode12,13,611/2/3TaxinolDocetaxel-tubulinIIIIHC1/2/3ABCB1(MDR1)(2677GT/A)4CYP1B1(Leu432Val)4STMN1IHC1/2/3Vinblastine-tubulinIIIIHC1/2/3ABCB1(MDR1)(2677GT/A)4CYP1B1(Leu432Val)4STMN1IHC1/2/3K-rascode12,13,611/2/3PemetrexedTYMS(TS)IHC1/2/3TYMS(TS)(TYMSTSER*2,*3)4GemcitabineRRM1IHC1/2/3CDAEtoposideTOPOIIIHC1/2/3GSTP1(Ile105Val)4IrinotecanUGT1A1(UGT1A1*1,*28,*6)4TOPOIIHC1/2/3MitomycinNQO1(C609T)4IfosfamideCYP2C9(CYP2C9*1,*2,*3)4CYP2C19(CYP2C19*1,*2,*3)4AbraxaneSPARCIHC1/2/3PD-1PD-L1sunitinibVEGFR1IHC1/2/3VEGFR2IHC1/2/3VEGFR3IHC1/2/3PDGFRIHC1/2/3EverolimusHER2IHC1/2/3ERIHC1/2/3K-rascode12,13()1/2/3K-ras(FQ-PCR)1/2/3PTENIHC1/2/3PIK3CAExon9,201/2/3PlatinumERCC1IHC1/2/3ERCC1(C118T)4ERCC2(Lys751Gln)4TPMT(TPMT*1,*2,*3A,*3B,*3C)4XRCC1(Arg399Gln)4GSTP1(Ile105Val)4GSTT14GSTM14TaxinolDocetaxelVincaleukoblastinum-tubulinIIIIHC1/2/3ABCB1(MDR1)(2677GT/A)4CYP1B1(Leu432Val)4STMN1IHC1/2/3GemcitabineRRM1IHC1/2/3CDA(A79C)4EtoposideTOPOIIIHC1/2/3GSTP1(Ile105Val)4IrinotecanUGT1A1(UGT1A1*1,*28,*6)4TOPOIIHC1/2/3DoxorubicinTOPOIIIHC1/2/3GSTP1(Ile105Val)4temozolomideMGMTMSP1/2/3CyclophosphamideIfosfamideCYP2C9(CYP2C9*1,*2,*3)4CYP2C19(CYP2C19*1,*2,*3)4TopotecanTOPOIIHC1/2/312341NCCN20151+PS0-12EGFREGFREGFR3EGFR4ALK5//6//782EGFRNSCLC1FASTACT-220136EGFR2015NCCN2ICOGEN3201393EGFRJO25567220148EGFRNSCLC422014115EGFR320151EGFRHER219EGFR6AZD9291EGFRNSCLC20154EGFREGFREGFRT790MAZD9291EGFRT790MEGFRNSCLC7RociletinibCO-1686EGFR20154RociletinibCO-1686T790MEGFRALKNSCLC1ALK20136ALK2CeritinibALK20143ALKALKNSCLCFDAALKNSCLC3ROS-1201411ALKROS12011826FDAALKNSCLCROS1NSCLC