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2012-04-23,tumorsuppressorgene;antioncogene;cancersuppressorgenep53(Rb)oncogenescancersuppressorgenestumorsuppressorgenesanti-oncogenesrasrasH-rasK-rasN-ras15%50%25%13p14Rbp53p5350%BRCA1BRCA2DPC4VHLM6P/IGF2r3p14.2FHITRbp53WTCKIp15p16p21rasGTPNF-1PTENDNABRCA1BRCA2APCAxinRbdominantnegativep53APCHaplo-insufficiencyDCC