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|2019ACancerJournalForClinicians20191,762,450606,88811.2.3.DNA4.5.6.7.1.11DatebaseDescriptioncanEvolveWebportalforintegrativeoncogenomicscBioPortalcBioPortalforCancerGenomicsCGAPCancerGenomeAnatomyProjectCGHubCancerGenomicsHubCGWBCancerGenomeWorkBenchCOSMICCatalogueOfSomaticMutationsInCancerICGCInternationalCancerGenomeConsortiumTCGATheCancerGenomeAtlasUCSCGenomeBrowserUCSCCancerGenomicsBrowser1.1canEvolve[1]canEvolvemicroRNA(miRNA)(CNAs)-1.2cBioPortalforCancerGenomics(cBioPortal)[2]cBioPortalforCancerGenomicsCNACANcBioPortal2cBioPortal1.3CancerGenomeAnatomyProject(CGAP)[3]CGAPcDNASNPCGAP3CGAP1.4CancerGenomicsHub(CGHub)[4]CGHub(NCI)(TCGA)(CCLE)()(TARGET)3251.5CancerGenomeWorkBench(CGWB)[5]CGWBTCGA1.6CatalogueofSomaticMutationsinCancer(COSMIC)[6]COSMICCNASNP4COSMIC1.7InternationalCancerGenomeConsortium(ICGC)[7]ICGC505ICGC1.8TheCancerGenomeAtlas(TCGA)[8]TCGANCImiRNA6TCGA1.9UCSCCancerGenomicsBrowser[9]UCSCCancerGenomicsBrowserCNAUCSC7UCSC2.CNASNP(CNAs)22DatebaseDescriptionarrayMapReferenceresourceforgenomiccopynumberimbalancesBioMutaIntegratedsequencefeaturedatabaseCanGEMCancerGEnomeMineCasSNPCopynumberalterationsofcancergenomefromSNParraydataCGPCancerGenomeProject2.1ArrayMap[10]ArrayMapCNAArrayMapCNACNA8ArrayMap2.2BioMuta[11]BioMutaBioMutaCOSMICClinVarUniProtKB9BioMuta2.3CancerGEnomeMine(CanGEM)[12]CanGEMArrayCGH10CanGEM2.4CancerGenomeProject(CGP)[14]CGPCNACNABioViewGRAFT11CGP3.DNADNADNADNA33DNADatebaseDescriptionDiseaseMethHumandiseasemethylationdatabaseMENTMethylationandexpressiondatabaseofnormalandtumortissuesMethDBCommonresourceforepigeneticphenomenonMethHCDNAmethylationandgeneexpressioninhumancancerMethyCancerHumanDNAMethylationandCancerNGSmethDBNext-generationsequencingsingle-cytosine-resolutionDNAmethylatio3.1DiseaseMeth[15]DiseaseMethDNADiseaseMeth12DiseaseMeth3.2MENT[16]MENTGeneExpressionOmnibus(GEO)TCGADNADNA13MENT3.3MethHCMethHCDNAmRNA/microRNA14MethHC[17]3.4MethyCancer[18]DNACpGIsland(CGI)MethyCancerDNA15MethyCancerMethDBNGSmethDBMethDBDNANGSmethDBSNP4.4DatebaseDescriptionArrayExpressMicroarraygeneexpressiondataChiTaRSChimerictranscriptsandRNA-sequencingdataGEOGeneExpressionOmnibusmiRCancerMicroRNAcancerassociationdatabaseOncomineCancermicroarraydatabaseOncomiRDBExperimentallyverifiedoncogenicandtumor-suppressivemicroRNAsSomamiRSomaticmutationsimpactingmicroRNAfunctionincancer4.1ArrayExpress[19]ArrayExpress(HTS)ArrayExpressMAGE-TAB16ArrayExpress4.2ChiTaRS[20]ChiTaRSRNA-SeqChiTaRSRNA-SeqGenBankChimerDBdbCRIDTICdb(ESTs)mRNA17ChiTaRS4.3GeneExpressionOmnibus(GEO)[21]GEO(NCBI)RNASNP18GEO4.4miRCancer[22]miRCancermiRNAmiRNA19miRCancer4.5Oncomine[23]Oncomine20Oncomine4.6OncomiRDB[24]OncomiRDBmiRNA4.7SomamiR[25]SomamiRmiRNAmiRNAmiRNA21SomamiR5.5DatebaseDescriptionCancer3DCancermutationsandproteinstructuresCancerPPDAnticancerpeptidesandproteinsCanProVarCancerProteomeVariationDatabaseCPTACClinicalProteomicTumorAnalysisConsortiumdbDEPCDifferentiallyexpressedproteinsinhumancancers5.1Cancer3D[26]Cancer3DTCGACCLEe-Drivere-Drug5.2CancerPPD[27]CancerPPD(ACPs)CancerPPDN-C-CancerPPDD-CancerPPDweb22CancerPPD5.3CancerProteomeVariationDatabase(CanProVar)[28]CanProVarCanProVarTCGACOSMICOMIMHPIGO5.4ClinicalProteomicTumorAnalysisConsortium(CPTAC)[29]CPTAC5.5DbDEPC[30]DbDEPC6.6DatebaseDescriptionDriverDBExomesequencingdatabaseforcancerdrivergeneNCGNetworkofCancerGenesTP53MULTLoadTP53mutationdatabaseUMDTP53TP53database6.1DriverDBDriverDBTCGAICGCTARGETexome-seq,23DriverDB6.2NetworkofCancerGenes(NCG)[31](NCG)miRNAmiRNA6.3TP53MULTLoad[32]TP53MULTLoadTP53UMDTP53TP53TP5324TP53MULTLoad7.7DatebaseDescriptionCancerDRCancerdrugresistancedatabaseCancerResourceCancer-relevantproteinsandcompoundinteractionscanSARCancerresearchanddrugdiscoveryknowledgebaseGDSCGenomicsofDrugSensitivityinCancerPlatinumMutationsonstructurallydefinedprotein-ligandcomplexes7.1CancerDRCancerDRCancerDR14895225CancerDR[33]7.2CancerResource[34]CancerResourceCancerResource26CancerResource7.3canSAR[35]canSARArrayExpressUniProtCOSMIC1127canSAR7.4GenomicsofDrugSensitivityinCancer(GDSC)[36]GDSCGDSC28GDSC7.5Platinum[37]Platinum1000Platinum29PlatinumReference:[1]SamurMK,YanZ,WangX,etal.canEvolve:AWebPortalforIntegrativeOncogenomics[J].PLOSONE,2013,8.[2]GaoJ,AksoyBA,DogrusozU,etal.IntegrativeAnalysisofComplexCancerGenomicsandClinicalProfilesUsingthecBioPortal[J].ScienceSignaling,2013,6(269):pl1-pl1.[3]StrausbergRL,BuetowKH,Emmert-BuckMR,etal.TheCancerGenomeAnatomyProject:buildinganannotatedgeneindex[J].TrendsinGeneticsTig,2000,16(3):103-106.[4]WilksC,ClineMS,WeilerE,etal.TheCancerGenomicsHub(CGHub):overcomingcancerthroughthepoweroftorrentialdata[J].Database,2014.[5]ZhangJ,FinneyRP,RoweW,etal.SystematicanalysisofgeneticalterationsintumorsusingCancerGenomeWorkBench(CGWB)[J].GenomeResearch,2007,17(7):1111-1117.[6]ForbesSA,BeareD,GunasekaranP,etal.COSMIC:exploringtheworldsknowledgeofsomaticmutationsinhumancancer[J].NucleicAcidsResearch,2015,43(D1):D805-D811.[7]BanksR,LopezOtn,Carlos.Internationalnetworkofcancergenomeprojects[J].Nature,2010,464(7291):993-998.[8]ChangK,Creigh