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(osteoarthritis,OA)20202007OAOAOA20176OAOAOAOAOAOAOA6550%OA()(ChinaHealthandRetire-mentLongitudinalStudy,CHARLS)OAKellgren&Lawrence8.1%(13.7%)(10.8%)(5.4%)(5.5%)0AOA3%()5.8%(OACroftX1.5mmOA1.1%0.9%0A0.59%OAOAOA1OAOAOAOA0A()1.OA36.8%60.7%OA2.30min3.0AHeberdenBouchard4.()OA()5.OA()1.XOAXOA()2.MRIMRIOAOA3.CTOA()C(C-reactiveproteinCRP)(erythrocytesedimentationrate,ESR)OA()OA1OA(1-3)()OAXKellgren&Lawrence(4)Outbridge(5)OAOA(2)()OA1.OA2.(1)(2)()(3)3.4.()OA1.nonsteroidalantiinflam-matorydrugs,NSAIDsOA1NSAIDsNSAIDs23NSAIDsNSAIDs(6)COX-2NSAIDsH2NSAIDs(COX-2)NSAIDs2.NSAIDsNSAIDs3.(1)23(2)OA(3)OA4.OAsymptomaticslow-actingdrugsforosteoarthritis,SYSADOAsOAOA5.OANSAIDsOA6OA()OA1.2.OAOA3.OA900.5cmOA0.5cm100OAKSSVAS4.OAOA5.OAOAOA106%17%2%7%70127055-641580%(71%)65741594%(85%)751090%OA1588%89%51015OA1568%71%KOS-ADISHAASOA1093%592%95%1525%1069%94%OAAOFASKofoedVAS