2019年多粘菌素最佳使用方法的国际共识指南

2019EB50MDRXDR1980BBAKIACCPESCMIDIDSAISAPSCCMSIDPGRADEGRADE/1MIC1EUCASTCLSIISO-7420776MICMuellerHinton-80-CLSI-EUCAST-CLSI/EUCAST1BBB2PK/PDB224-(AUCss,24h)50mg?h/L(Cssavg)2mg/LAKI3BBAUCss,24hBTDBAUCss,24h50100mg*h/LCss,avg24mg/L4BBMIC35CMSB6BB7CMS4CMS8CMSIUCBA100IU33mgCBA5CMS9CMS0.5-1300mgCBA900IU12-246CMS10300-360mgCBA900-1090IUq12h0.5-127CMS1128CMS12IHDCss,avg2mg/LCMS130mgCBA/d395IU/d3-440mgCBA/d120IU/d50mgCBA/d160IU/dCMS13SLEDCss,avg2mg/LSLED110%/CMS14CRRTCss,avg2mg/L440mgCBA/d133IU/d12220mgCBA665IU/q12hB9B15TBWB2.0-2.5mg/kg20,000-25,000IU/kg110B1612B1.25-1.5mg/kg12,500-15,000IU/kgTBW111B17B12B18B13B19TDMAFCCMSB14CMSBAKI20B21TDMCMSB22/BAKI2315BAKI24AKI2Css,avg2mg/L25MIC1mg/LBMIC26AKI16CREB27CREBMIC28CREMICBMICMIC17CRABB29CRABBMIC30CRABMICB31CRPABMIC32CRPAMICBMICMIC18HAP/VAP33XDRHAP/VAP)34B1935IVTITH125,000IU/dCMS(4.1mgCBA)or5mg/d(50,000IU)BMRDXDR36BCMSIVTITHPharmacotherapy.2019;39(1):10-39