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36320095InternationalJournalofStomatologyVol.36No.3May2009[]2008-10-29[]2008-12-16[]1983-[]Tel028-85501428。207020903%～4%。2。worldhealthorganizationWHOHodgkinlymphomaHLnon-HodgkinlymphomaNHLBT/HL10.9%NHL89.1%[1]。NHL。、、/。NHL。1、sur-veillanceepidemiologyandendresultsSEERNHL。2000—2003NHL672%2047%65848%84。NHL。25～54NHL。NHL。22.1NHL。EBEpstein-BarrvirusEBVT。。NHL。（，610041）[]30。。。。[][]R363.1[]AResearchprogressontheroleofenvironmentalfactorsintheetiologyofnon-HodgkinlymphomaLIXin,LILong-jiang.StateKeyLaboratoryofOralDiseases,SichuanUniversity,Chengdu610041,China[Abstract]Thelastthirtyyearssawariseintheincidenceofnon-Hodgkinlymphoma,anditisnowoneofthemostcommonneoplasms.Lymphomagenesisisacomplexprocessandthatmanyofthepathologicsubtypesoflymphomahavedifferentetiologies.Thus,thestudyofenvironmentalfactorsbecomesmoreandmoreimportant.Thispaperreviewedtheresearchadvanceontheroleofenvironmentalfactorsintheetiologyofnon-Hodgkinlymphoma.[Keywords]non-Hodgkinlymphomariskepidemiologyimmunosuppressioninfection323··36320095InternationalJournalofStomatologyVol.36No.3May2009。、、、NHL。2NHL。NHL。。Askling[2]1～3、。。EB。EBV。EBV。Opelz[3]。1959385。239.5。2.2EB、hu-manimmunodeficiencyvirusHIV、T-1、－8。DNA3。EBVBurkitt。EBV。。EBVBB。B[4]。T。EB。。NHL[5]。Cortes[6]HIVNHL150～250NHL16％。HIV。。BurkittEBV30%40%2。EBV[7]。。highlyactiveantire-troviraltherapyHAARTHIVNHL。B。Bower[8]HAARTHIVNHL。1978T-1T/adultTcellleukemia/lymphomaATLL。、1%～5%ATLL[9]。ATLL55。mucosa-associatedlymphoidtissuelymphomaMALTB。。0.01％MALT[10]。MALTT[11]。－8、、－40、、jejuneiNHL。。324··36320095InternationalJournalofStomatologyVol.36No.3May200933.11966“”。statinsH25-T/BNHL[12]。statins。。DNAT。。。3.2//。2,4-[13-14]。2,4-50％～200％3～8。Cantor[15]。Hayes[16]10。。3.3[17]。1979。1980。1980。。23022417[18]。37%～38%19%。。。4[1]HarrisNL,JaffeES,DieboldJ,etal.AnnOncol,1999,10121419-1432.[2]AsklingJ,KlareskogL,HjalgrimH,etal.AnnRheumDis,2005,64121765-1768.[3]OpelzG,DohlerB.AmJTransplant,2004,42222-230.[4]Thorley-LawsonDA,GrossA.NEnglJMed,2004,350131328-1337.[5]DalMasoL,FranceschiS.LancetOncol,2003,42110-119.[6]CortesJ,ThomasD,RiosA,etal.Cancer,2002,9451492-1499.[7]CarboneA,GloghiniA.BrJHaematol,2005,1305662-670.[8]BowerM,GazzardB,MandaliaS,etal.AnnInternMed,2005,1434265-273.[9]MurphyEL,FigueroaJP,GibbsWN,etal.AmJEpi－demiol,1991,133111114-1124.[10]HoughtonJ,FoxJG,WangTC.JGastroenterolHepatol,2002,174495-502.[11]ChengTY,LinJT,ChenLT,etal.JClinOncol,2006,24213483-3489.[12]NihalM,MikkolaD,HorvathN,etal.HumPathol,2003,346617-622.[13]DeRoosAJ,ZahmSH,WeisenburgerDD,etal.OccupEnvironMed,2003,609E11.[14]QuintanaPJ,DelfinoRJ,KorrickS,etal.EnvironHealthPerspect,2004,1128854-861.[15]CantorKP,StricklandPT,BrockJW,etal.EnvironHeal-thPerspect,2003,1112179-183.[16]HayesRB,YinSN,DosemeciM,etal.JNatlCancerInst,1997,89141065-1071.[17]ZhangY,HolfordTR,LeadererB,etal.AmJEpi－demiol,2004,1592148-154.[18]deSanjoséS,BenaventeY,NietersA,etal.AmJEpide-miol,2006,164147-55.325··